Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Zanoterone	NCIT_C74123
PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1	NCIT_C49178	[A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) encapsulated in a biodegradable, biocompatible lipoplex composed of polyethylene glycol (PEG), polyethylenimine (PEI), and cholesterol, with potential immunoactivating and antineoplastic activities. Upon intraperitoneal (IP) delivery of the PEG-PEI-cholesterol lipopolymer-encased IL-12 DNA plasmid vector GEN-1, the lipoplex is endocytosed by nearby cells, and the plasmid DNA is transported into the nucleus, which leads to local expresssion of IL-12. In turn, the increased IL-12 production at the tumor site activates the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma (IFN-g) and promoting cytotoxic T-cell responses against tumor cells.]
Amafolone	NCIT_C74124
Conventional Cardiac Rhabdomyoma	NCIT_C49179	[A cardiac rhabdomyoma characterized by the presence of neoplastic large striated muscle cells with clear cytoplasm and spider cells.]
Cardiac Rhabdomyoma	NCIT_C6739	[A well circumscribed benign tumor arising from cardiac muscle. It usually affects children and may be present in the fetus. Depending on tumor location and size, cardiac, respiratory, and hemodynamic parameters may be affected. There is an association between cardiac rhabdomyoma and tuberous sclerosis.]
Ubisindine	NCIT_C74125
Aprepitant	NCIT_C49173	[A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.]
Retinoblastoma cM1d TNM Finding v7	NCIT_C88781	[Postchiasmatic CNS lesion(s). (from AJCC 7th Ed.)]
MK0731	NCIT_C49174	[A synthetic small molecule with potential antineoplastic activity. MK0731 selectively inhibits kinesin spindle protein (KSP), which may result in the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and apoptosis in tumor cells that overexpress KSP.]
Mitotic Kinesin Modulator	NCIT_C67440	[A class of compounds that modulate the activity of mitotic kinesins. Mitotic kinesins or microtubule-associated proteins (MAPs) are ATP-powered proteins that convert energy into a mechanical force along the microtubule structure following the hydrolysis of ATP, which occurs during microtubule polymerization. Mitotic kinesins play an essential role in regulating the formation of the mitotic spindle as well as regulating their function. Agents that modulate the activity of kinesins, specifically those that produce inhibitory effects, interfere with mitotic spindle assembly, organization and eventually, chromosome alignment and segregation, thereby inducing mitotic arrest.]
Retinoblastoma cM1e TNM Finding v7	NCIT_C88782	[Leptomeningeal and/or CSF involvement. (from AJCC 7th Ed.)]
Notch Signaling Pathway Inhibitor MK0752	NCIT_C49175	[A synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation.]
Carcinoma of the Lacrimal Gland TNM Finding v7	NCIT_C88783	[A finding about one or more characteristics of carcinoma of the lacrimal gland, following the rules of the TNM AJCC v7 classification system. No stage grouping is presently recommended for carcinoma of the lacrimal gland. (from AJCC 7th Ed.)]
Palbociclib	NCIT_C49176	[An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.]
Carcinoma of the Lacrimal Gland Pathologic TNM Finding v7	NCIT_C88784	[A pathologic finding about one or more characteristics of carcinoma of the lacrimal gland, following the rules of the TNM AJCC v7 classification system. Complete resection of the mass is indicated. The specimen should be thoroughly sampled for evaluation of histologic type and grade of tumor, size, possible presence of a preexisting pleomorphic adenoma, and surgical margins (including the periosteum). (from AJCC 7th Ed.)]
Neoplastic Striated Muscle Cell with Eosinophilic Granular Cytoplasm	NCIT_C49170
Rhabdomyoblast	NCIT_C36744
Primitive Skeletal Spindle Cell	NCIT_C49171
Primitive Skeletal Muscle Cell	NCIT_C49200
11C Topotecan	NCIT_C49172	[A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata radiolabeled with carbon 11 (11C) with antineoplastic and radiotracer properties. During the S phase of the cell cycle, topotecan inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Quantitation of 11C topotecan accumulated in tumor tissues by positron emission tomography (PET) may help predict responses to topotecan therapy.]