Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Anti-TROP2/DXd Antibody-drug Conjugate DS-1062a	NCIT_C151967	[An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody against tumor-associated antigen (TAA) trophoblast cell surface protein 2 (calcium signal transducer 2; TROP2; TROP-2; TACSTD2) conjugated, via an enzymatically cleavable tetrapeptide-based linker, to the cytotoxic DNA topoisomerase I inhibitor and exatecan (DX-8951) derivative DXd (MAAA-1181a; MAAA-1181), with potential antineoplastic activity. Upon administration of the anti-TROP2/DXd ADC DS-1062a, the anti-TROP2 antibody targets and binds to TROP2 expressed on tumor cells. Upon cellular uptake and lysosomal degradation of the linker, DXd targets and binds to DNA topoisomerase I, thereby stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication and apoptosis. This inhibits tumor cell proliferation of TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors while its expression is low and/or restricted in normal, healthy tissues. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival. The ADC allows for reduced systemic exposure and enhanced delivery of the cytotoxic agent DXd.]
Donor-derived CD34+ Hematopoietic Stem and Progenitor Cells Plus CD3+ T-cells MDR-101	NCIT_C151968	[A preparation of allogeneic, organ donor-derived CD34-positive hematopoietic stem and progenitor cells (HPCs) and CD3-positive T-cells that can be used after organ transplantation to potentially prevent organ rejection. Upon infusion of the organ donor-derived CD34+ HPCs plus CD3+ T-cells MDR-101 after organ transplantation, these cells mix and co-exist with the recipient's blood and immune cells, thereby inducing hematologic mixed chimerism and enabling the recipient's immune system to become immune tolerant to the donor cells. This increases acceptance of the transplanted organ, decreases the risk of organ transplant rejection, increases organ survival and may decrease the need for additional immunosuppressive agents. The cells in MDR-101 are ex vivo processed in a specific and unique way which has yet to be fully elucidated. Cell doses are dependent on the degree of human leukocyte antigen (HLA)-match/HLA-mismatch between the recipient and donor.]
Indium In 111 Monoclonal Antibody HuJ591	NCIT_C151969	[A radioimmunoconjugate containing the recombinant humanized monoclonal antibody J591 directed against the extracellular domain of prostate-specific membrane antigen (PSMA) and labeled with the gamma-emitting isotope indium 111 (In 111; 111In), with potential radioimaging application. Upon administration, indium In 111 monoclonal antibody J591 targets and binds to PSMA expressed on tumor cells. The use of gamma scintigraphy allows for the detection and imaging of the radioactive In 111, which can be used to determine the distribution and tumor localization of PSMA. PSMA is a transmembrane peptidase that is highly expressed on prostate tumor cells.]
Acustimulation Therapy	NCIT_C15761	[Use of a low intensity electrical current to provide mild stimulation of the body's acupuncture points in order to control symptoms such as nausea and vomiting.]
Acupuncture Therapy	NCIT_C15176	[The practice of piercing specific points on the body with very thin sterile needles in order to relieve pain or induce regional anesthesia.]
Laparoscopic Colectomy	NCIT_C15762	[Surgical removal of part or all of the colon, using a laparoscope.]
Colectomy	NCIT_C15209	[Surgical removal of part or all of the colon.]
Therapeutic Laparoscopic Surgery	NCIT_C65014
Advanced Manufacturing Technology	NCIT_C15763	[Activities, including research and development efforts, leading to new or improved manufacturing processes, equipment, or techniques, as well as related activities to manage and deploy manufacturing technologies.]
AIDS, Clinical Trials on Patients with AIDS-Related Malignancies	NCIT_C15764	[Clinical trials related to the development of vaccines and therapeutics directed against AIDS-related malignancies. These trials include the following malignancies: Kaposi's sarcoma, non-Hodgkins lymphoma, other lymphomas, and lymphosarcomas.]
AIDS Clinical Trial	NCIT_C51359	[A clinical trial designed to evaluate the development, safety, and efficacy of vaccines and therapeutics directed against AIDS.]
AIDS, Clinical Trials on Minorities	NCIT_C15765	[AIDS clinical trials related to individuals of non-Caucasian descent.]
AIDS, Clinical Trials on Patients with Opportunistic Infections	NCIT_C15766	[Clinical trials related to the development of vaccines and therapeutics directed against opportunistic infections associated with HIV infection. These trials include the following opportunistic infections: pneumocystosis, toxoplasmosis, cryptosporidiosis, candidacies, cryptococcosis, mycobacteriosis, cytomegalovirus, papillomavirus, herpes simplex, JC virus, coccidioides, hairy leukoplakia, and HIV-related periodontal disease.]
AIDS, Clinical Trials on Children	NCIT_C15767	[AIDS clinical trials related to children 0-18 years of age. These trials include pregnant females, neonates, and infants.]
Receptor Activation Process	NCIT_C40702	[Any intercellular signaling process in which a transmembrane or intracellular receptor in the responding cell binds to a cognate ligand and initiates an intracellular response. Receptor activation is involved in numerous processes, including metabolism, immune response, sexual development, nervous system function, and regulation of circadian rhythms, mood and behavior.]
AIDS, Clinical Trials on Women	NCIT_C15768	[AIDS clinical trials related to females 12 years of age or older. These trials include pregnant women, women at risk of AIDS, female prostitutes, and women who have perinatally transmitted AIDS to a fetus or newborn.]
Basic Behavioral and Social Science Research	NCIT_C15769	[Basic social sciences and behavioral research designed to strengthen the understanding of (a) the determinants and processes that influence HIV-related risk behaviors and (b) the consequences of HIV disease.]
Behavioral Research	NCIT_C15185	[Studies of the motivating factors that influence health practices as well as efforts to modify these practices.]
Nairovirus	NCIT_C112358	[A genus of enveloped, spherical viruses in the family Bunyaviridae. The genome is composed of a circular single-strand of negative sense RNA. Nairoviruses are tick-borne with human and animal hosts and cause hemorrhagic fevers and gastroenteritis in humans.]
Nipah Virus	NCIT_C112359	[A species of enveloped and pleomorphic viruses in the Paramyxoviridae family and Henipavirus genus. The genome is composed of non-segmented, negative-sense, single-stranded RNA. Nipah viruses are found naturally in Pteropid fruit bats, and are zoonotic pathogens in domestic animals (mainly in pigs) and humans. Nipah viruses cause respiratory diseases, relapse and fatal encephalitis in humans.]