Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Agent Affecting Musculoskeletal System	NCIT_C78281	[Any agent that exerts an effect on muscle, bones and joints.]
HPV16-E6-T27	NCIT_C151956	[A transcription activator-like effector nucleases (TALEN)-edited plasmid targeting the human papillomavirus (HPV) type 16 (HPV16) epitope E6, with potential antineoplastic activity. Upon administration of TALEN-edited HPV16 E6 T27, the TALEN targets and binds to a specific site on genomic HPV16 E6 and cleaves the DNA sequences encoding E6. This causes double-strand DNA (dsDNA) breaks within the viral DNA, which prevents the transcription and translation of E6. Inhibition of E6 expression restores and increases the expression of tumor suppressor genes, such as p53, and proapoptotic protein BAK, and promotes downstream signaling. Altogether, TALEN-based HPV editing increases apoptosis, reduces viral replication and viral load, eliminates HPV and inhibits tumor cell proliferation of HPV-driven cancer cells. HPV16 E6 is an oncogene vital to viral function and HPV infection, and promotes carcinogenesis.]
Transformed Non-Hodgkin Lymphoma	NCIT_C151957	[Histologic transformation of an indolent non-Hodgkin lymphoma to an aggressive non-Hodgkin lymphoma.]
HPV16-E7-T512	NCIT_C151958	[A transcription activator-like effector nucleases (TALEN)-edited plasmid targeting human papillomavirus (HPV) type 16 (HPV16) epitope E7, with potential antineoplastic activity. Upon administration of TALEN-edited HPV16 E7 T512, the TALEN targets and binds to a specific site on genomic HPV16 E7, and cleaves the DNA sequences encoding E7. This causes double-strand DNA (dsDNA) breaks within the viral DNA, which prevents the transcription and translation of E7. Inhibition of E7 expression restores and increases the expression of tumor suppressor genes, such as retinoblastoma 1 (RB1), and promotes downstream signaling. Altogether, TALEN-based HPV editing increases cell cycle arrest, induces apoptosis, reduces viral replication and load, eliminates HPV and inhibits tumor cell proliferation of HPV-driven cancer cells. HPV16 E7 is an oncogene that is vital to viral function and HPV infection, and promotes carcinogenesis.]
Negative Regulation of Cell-Cell Adhesion	NCIT_C40709	[Any cellular process that reduces the frequency, rate or extent of adhesion between cells.]
Behavior Research, Direct	NCIT_C15770	[Research concerning people's behavior in the context of cancer, i.e., how people's behavior affects their chance of developing cancer.]
Behavior Research, Indirect	NCIT_C15771	[Research concerning any factor or condition, exposure to which is theoretically susceptible to behavioral modification, but in which no actual behavioral work is being done (e.g., experimental studies on tobacco use, consumption of various dietary components, and exposure to many other environmental carcinogens).]
Biological Response Modifiers Program	NCIT_C15772	[A program set up to establish cooperative agreements for Clinical Trials of Cancer Therapy with Biological Response Modifiers (CATBRMs) and to develop novel approaches for such therapy. Funding is provided to foster innovative clinical trials of BRMs by peer-reviewed groups of highly experienced clinical and preclinical investigators who have the unique technical capabilities to study new agents in early clinical trials and to address hypothesis-driven issues of mechanisms of action.]
Leukocyte Banking	NCIT_C15773	[The typing, separation, and storage of leukocytes for subsequent transfusion to recipients.]
Repository Operation	NCIT_C15977
Breast Cancer Therapeutic Procedure	NCIT_C15774	[Medical or surgical interventions to eradicate breast tumors and/or their metastases.]
Breast Cancer Diagnostic or Therapeutic Procedure	NCIT_C79427
Breast Cancer Detection Research	NCIT_C15775	[Research project involving detection of breast tumors (screening, diagnosis clinical trials), development or refinement of diagnostic techniques or devices, education or promotion of breast cancer detection.]
Cancer Detection	NCIT_C15776	[The act of discovery of a malignant neoplasm, and after treatment, the discovery of minimal residual disease.]
Detection	NCIT_C16210	[The activity of perceiving, discerning, discovering or identifying.]
Cancer Prevention, Primary	NCIT_C15777	[NIH Emphasis Area -- The term "prevention" refers to prophylactic and preventative efforts to achieve a significant reduction in cancer incidence, cancer mortality, and cancer morbidity. "Primary prevention" involves efforts to directly prevent and/or inhibit malignant transformation; to identify, characterize, and manipulate factors that might be effective in achieving that inhibition; and attempts to promote preventative measures, such as appropriate training of scientists and clinicians. Prevention and intervention efforts are biologic activities aimed at the cell - at the genetic and cellular changes that result in the transformation process and that define cancer development]
Primary Prevention	NCIT_C15306	[Prevention of disease or mental disorders in susceptible individuals or populations through promotion of health, including mental health, and specific protection, as in immunization, as distinguished from the prevention of complications or after-effects of existing disease.]
Cancer Prevention, Secondary	NCIT_C15778
Carcinogen Screening	NCIT_C15779	[In vitro or in vivo testing to give a quantitative measure of tumor-inducing potency of the substance.]
Negative Regulation of Hemolytic Process	NCIT_C40736	[Any process that decreases the frequency, rate or extent of hemolysis.]