Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Artemisinin Dimer	NCIT_C60769	[A sesquiterpene lactone peroxide and dimerized plant product derived from Artemisia annua L with anti-malarial, anti-proliferative and anti-angiogenic effects. Artemisinin contains an endoperoxide moiety which forms free radicals when it reacts with iron. The resultant carbon-based radical can lead to cellular damage and cell death by reacting with cellular macromolecules such as proteins and membrane lipids. Malaria parasites contain large amounts of heme-iron, a product from the digestion of hemoglobin. However, recently it has been suggested that activation of artemisinin inside the parasite is by ferrous iron. Furthermore, due to their rapid rate of division, cancer cells require and uptake a large amount of iron to proliferate, therefore they are more susceptible to the cytotoxic effect of artemisinin than non-cancerous cells. The dimer configuration has been shown to increase compound stability and reduce general toxicity.]
Antimalarial Agent	NCIT_C271	[Agents used to treat malaria, and are usually classified based on action against plasmodia at different stages in their life cycle in the human.]
Terpene Compound	NCIT_C860	[The class of compound known as terpenes comprise of essential oils, flavours and fragrances. The extraction and synthesis of compounds such as these is the basis for the perfumery industry. They find a variety of uses in the food and pharmaceutical industry as flavour and odour improvers]
Medical Research Council Dyspnea Scale	NCIT_C21157	[A scale grading dyspnea from 0 (not troubled with breathlessness except with strenuous exercise) to 4 (too breathless to leave the house or breathless when dressing or undressing). (Brooks 1982)]
Abstract	NCIT_C60765	[A written summary of the important points of a scientific article.]
Summary	NCIT_C42581	[A shortened version of a speech or written text, containing only the main points.]
ATS-DLD-78 Adult Questionnaire	NCIT_C21158	[A questionnaire designed by the American Thoracic Society that assesses cough, phlegm, wheezing, breathlessness, illness and risk factors. (Brooks 1982)]
Indium In 111 CHX-A DTPA Trastuzumab	NCIT_C60766	[An indium In 111-labeled trastuzumab with potential use as an imaging agent. Indium In 111 CHX-A DTPA trastuzumab is chemically conjugated via a bifunctional metal chelator molecule, 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A DTPA), a backbone-substituted derivative of DTPA. This agent may allow radioimmunolocalization of HER2-positive cells. Trastuzumab, a recombinant humanized monoclonal antibody that selectively binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2), may elicit an antibody-dependent cellular cytotoxicity (ADCC) against tumor cells that overexpress HER2.]
Radioimmunoconjugate	NCIT_C1511	[Monoclonal antibodies (MoAb) conjugated with radioisotopes, i.e., I-131, Y-90, T-99, or In-111. Using radioimmunoconjugates in radiotherapy or radioimaging has the advantage of targeting cells carrying specific antigens, thereby limiting toxic effects on normal cells. Tumor eradication can be achieved by either the antibody-mediated immune response or by only the cytotoxic activity of the radiation.]
Protein Family	NCIT_C20130	[Collection of proteins that are evolutionarily related. This is reflected in the structural and functional similarities as well as in the extent of sequence conservation or residue identity. (from SCOP)]
Metallopeptidase	NCIT_C16843	[A proteolytic enzyme that uses a metal ion, usually zinc, to catalyze the hydrolysis of peptide bonds. This protease is inhibited by metal chelating agents.]
SDZ 280-446	NCIT_C60767	[A novel semi-synthetic derivative of cyclosporin and a cyclodepsipeptide with chemo-sensitizing activity. SDZ 280-446 is one of the drug resistance-modifying agents that inhibit P-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activities of some drugs in drug-resistant tumor cells.]
Multidrug Resistance Modulator	NCIT_C1744
Veliparib	NCIT_C60768	[A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation.]
Poly (ADP-Ribose) Polymerase Inhibitor	NCIT_C62554	[Any substance that inhibits Poly (ADP-Ribose) polymerase, an enzyme involved in detecting DNA single strand breaks and the initiation of DNA repair. Inhibition of Poly (ADP-Ribose) polymerase has direct cytotoxic effects by inhibiting DNA repair and causing cell death.]
Beta-Microseminoprotein Family	NCIT_C21164
Cytokine Receptor Gene	NCIT_C20912	[Cytokine Receptor Genes encode cell surface Cytokine Receptors that bind paracrine or autocrine cytokine growth factors that stimulate humoral and cellular immune responses, as well as activation of phagocytic cells. Cytokines are secreted by inflammatory leukocytes (lymphokines), by monocytes or macrophages (monokines), and by various other cells. Interleukin lymphokines, targeted to cells of hematopoietic origin, are not secreted by leukocytes but affect the cellular responses of leukocytes. (NCI)]
CD72 Gene	NCIT_C21166	[This gene plays a role in signal transduction that leads to B-cell differentiation.]
B Cell Proliferation	NCIT_C19385	[Growth and reproduction of B-lymphocytes.]
Gallon per Day	NCIT_C69100	[A volumetric flow rate defined as the rate at which a certain amount of fluid, expressed in gallons, crosses a given surface or is delivered to a given object or space during the period of time equal to one day.]