Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
RB1CC1 wt Allele	NCIT_C88177	[Human RB1CC1 wild-type allele is located in the vicinity of 8q11 and is approximately 92 kb in length. This allele, which encodes RB1-inducible coiled-coil protein 1, plays a role in both autophagy and cell cycle regulation. Mutation of the gene may be associated with breast carcinoma and other cancers.]
8q11	NCIT_C13585	[A chromosome band present on 8q]
RB1-Inducible Coiled-Coil Protein 1	NCIT_C88178	[RB1-inducible coiled-coil protein 1 (1594 aa, ~183 kDa) is encoded by the human RB1CC1 gene. This protein is involved in the regulation of both autophagosome formation and the cell cycle.]
Protein Serine/Threonine Phosphatase Gene	NCIT_C26064	[Protein Serine/Threonine Phosphatase Genes encode Protein Serine/Threonine Phosphatases, a group of enzymes that specifically dephosphorylate phosphoserine and phosphothreonine residues in specific target proteins. Together with serine/threonine protein kinases, these enzymes regulate serine and threonine phosphorylation and dephosphorylation of target proteins in cellular signal transduction pathways typically involved in cell growth control. (NCI)]
Cell Cycle Progression	NCIT_C28683	[The cell cycle is an ordered set of events. Progression through the stages of cell cycle, including G1-S-G2-M, culminates in cell growth and division into two daughter cells.]
Glypican-5	NCIT_C88172	[Glypican-5 (572 aa, ~64 kDa) is encoded by the human GPC5 gene. This protein plays a role in heparin sulfate binding.]
GPC3 Gene	NCIT_C88173	[This gene is involved in heparin sulfate binding.]
Wilms Tumor	NCIT_C3267	[An embryonal neoplasm characterized by the presence of epithelial, mesenchymal, and blastema components. The vast majority of cases arise from the kidney. A small number of cases with morphologic features resembling Wilms tumor of the kidney have been reported arising from the ovary and the cervix.]
GPC3 wt Allele	NCIT_C88174	[Human GPC3 wild-type allele is located in the vicinity of Xq26.1 and is approximately 622 kb in length. This allele, which encodes glypican-3 protein, plays a role in the modulation of cellular interactions with extracellular proteoglycans. Mutation of the gene is associated with Simpson-Golabi-Behmel syndrome and Wilms tumor.]
Glypican 3 Signaling Pathway	NCIT_C91607
Xq26.1	NCIT_C13670	[A chromosome band present on Xq]
Glypican-3	NCIT_C88175	[Glypican-3 (580 aa, ~66 kDa) is encoded by the human GPC3 gene. This protein is involved in the mediation of proteoglycan binding to the cell surface.]
Stage IIIA Mycosis Fungoides and Sezary Syndrome AJCC v7	NCIT_C88158	[Stage IIIA includes: T4, N0-2, M0, B0. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). (AJCC 7th ed.)]
Stage III Mycosis Fungoides and Sezary Syndrome AJCC v7	NCIT_C88157	[Stage III includes: (T4, N0-2, M0, B0-1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 7th ed.)]
Stage IIIB Mycosis Fungoides and Sezary Syndrome AJCC v7	NCIT_C88159	[Stage IIIB includes: T4, N0-2, M0, B1. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. (AJCC 7th ed.)]
Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v7	NCIT_C88160	[Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. May further stratify into T1a (patch only) vs. T1b (plaque +/- patch). T2: Patches, papules, or plaques covering 10% or more of the skin surface. May further stratify into T2a (patch only) vs. T2b (plaque +/- patch). T3: One or more tumors (equal or greater than 1 cm diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone. (AJCC 7th ed.)]
Mycosis Fungoides and Sezary Syndrome by AJCC v7 Stage	NCIT_C141142	[A term that refers to the staging of mycosis fungoides and Sezary syndrome, following the rules of the TNM AJCC v7 classification system.]
Pedometer	NCIT_C88165	[An instrument for counting the number of steps taken while walking. This information can be used to estimate the distance traveled or calories used.]
Accelerometer	NCIT_C88166	[An instrument used for measuring a change in velocity.]
HRG wt Allele	NCIT_C88168	[Human HRG wild-type allele is located in the vicinity of 3q27 and is approximately 12 kb in length. This allele, which encodes histidine-rich glycoprotein, may play a role in both extracellular ion sequestration and coagulation. Mutation of the gene is associated with thrombophilia.]