Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Nucleoporin	NCIT_C21183	[Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The proteins encoded by these genes function in the nuclear transport of protein and RNA. (from LocusLink 4928, OMIM 601021)]
Structural Protein	NCIT_C18073	[Proteins whose major function is to give shape and support to tissues, cells, and subcellular structures.]
Nuclear Membrane	NCIT_C13265	[The double-layer membrane structure enclosing the nucleus in eukaryotic cells. It separates the DNA of the cell from the cytosol. For exchange of material, for example, proteins and mRNA, it is punctured with numerous nuclear pores.]
Nucleoporin Gene	NCIT_C20819	[These genes encode proteins that function in the nuclear transport of protein and RNA. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. (from LocusLink 4928, OMIM 601021)]
Nucleocytoplasmic Transport	NCIT_C19415	[The transport of material in and out of the nucleus through the nuclear membrane.]
Nuclear Pore Complex Protein Nup98	NCIT_C21184	[Nuclear pore complex protein Nup98 (880 aa, ~92 kDa) is encoded by the human NUP98 gene. This protein is involved in mitotic progression, regulation of gene expression and bidirectional transport across the nuclear pore complex.]
NUP98 Gene Product	NCIT_C136695	[A protein encoded by the NUP98 gene.]
RNA Recognition Motif	NCIT_C13720	[RNA Binding Domains (RBD) mediate the interaction of RNAs with RNA-binding proteins. RBDs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RBDs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA.]
Acute Myeloid Leukemia	NCIT_C3171	[A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification).]
Nuclear Pore	NCIT_C13266	[An octagonal opening, about 70 nm across, where the inner and outer membranes of the nuclear envelope are continuous.]
NUP98 Gene	NCIT_C20820	[This gene plays a role in transport and is frequently overexpressed in prostate cancers.]
Docking	NCIT_C19407	[A binding interaction that results in localization of the ligand.]
NPM1 Gene	NCIT_C21185	[This gene is involved in the regulation of ribosomal assembly.]
Acute Myeloid Leukemia with Mutated NPM1	NCIT_C82431	[An acute myeloid leukemia with mutation of the nucleophosmin gene. It is usually associated with normal karyotype and frequently has myelomonocytic or monocytic features. It usually responds to induction therapy.]
Non-Hodgkin Lymphoma	NCIT_C3211	[Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.]
Myelodysplastic Syndrome	NCIT_C3247	[A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)]
Chloride Intracellular Channel Protein 4	NCIT_C21180	[Chloride intracellular channel protein 4 (253 aa, ~29 kDa) is encoded by the human CLIC4 gene. This protein plays a role in ion channel activity.]
Ion Channel Protein	NCIT_C28505	[Ion Channel Proteins typically aggregate in membrane-associated complexes forming pores whose activities regulate the movement of ions through cellular membranes to affect cellular homeostatic conditions and/or signaling processes. (NCI)]
NOVA Family	NCIT_C21181	[Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI)]
NOVA Family Gene	NCIT_C20818	[Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI)]