Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Grade 5 Pancreatic Duct Stenosis, CTCAE	NCIT_C146468	[Death]
Clinical Trial	NCIT_C15207
Cohort Study	NCIT_C15208	[A research study that compares a particular outcome (such as lung cancer) in groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke compared with those who do not smoke).]
Combined Lung Large Cell Neuroendocrine Carcinoma	NCIT_C7267	[A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma.]
Lung Large Cell Neuroendocrine Carcinoma	NCIT_C5672	[A high grade malignant neoplasm that arises from the lung and is characterized by the presence of large neuroendocrine cells. It usually has an aggressive clinical course.]
Combined Lung Carcinoma	NCIT_C7591	[A lung carcinoma characterized by the presence of large or small neuroendocrine carcinoma cells in combination with malignant glandular or squamous epithelial cells.]
Minimally Invasive Lung Mucinous Adenocarcinoma	NCIT_C7268	[A morphologic variant of minimally invasive lung adenocarcinoma characterized by tall columnar cells and mucin production.]
Minimally Invasive Lung Adenocarcinoma	NCIT_C2923	[A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is characterized by a predominantly lepidic pattern and 5 mm or less invasion in greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely may be mucinous.]
Minimally Invasive Lung Non-Mucinous Adenocarcinoma	NCIT_C7269	[A morphologic variant of minimally invasive lung adenocarcinoma characterized by the presence of Clara cells and/or type II cells.]
Pristane	NCIT_C29850	[A natural or synthetic isoprenoid hydrocarbon (C19) derivative, Pristane is commonly used in research to prime the abdomen prior to hybridoma implantation in experimental animals. An irritant that induces granulomatous inflammation and interferes with local lymphatic drainage, it increases ascitic yields. Pristane has a low margin of safety and is toxic at levels slightly higher than used to prime animals. (NCI04)]
Off Study	NCIT_C29851	[No longer participating in a study; not being followed and will not be retreated.]
Rebamipide	NCIT_C29852	[A quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.]
Silicon Dioxide	NCIT_C29853	[A natural compound of silicon and oxygen found mostly in sand, Silica has three main crystalline varieties: quartz, tridymite, and cristobalite. Fine particulate silica dust from quartz rock causes over a long-term progressive lung injury, silicosis. (NCI04)]
Carcinogenic Mineral	NCIT_C45385	[An inorganic, crystalline solid substance with a well-defined chemical composition and with characteristic physical properties that is found in nature and has the ability to increase human cancer risk. (NCI05)]
Sulindac Sulfide	NCIT_C29854	[The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04)]
Theaflavin	NCIT_C29855	[A class of natural flavonoids derived from the dried leaves of the plant Camellia sinensis (tea) and related plants with potent antioxidant properties. Theaflavins are polymers derived from natural catechins which are oxidized upon drying of the plant leaf. Flavonoids such as theaflavins neutralize free-radical species and increase the activity of detoxifying phase II enzymes in the liver. In animal studies, theaflavins have been shown to exhibit antitumor effects by inducing tumor cell apoptosis, arresting cell division, inhibiting cancer cell invasion, and blocking growth factor-induced angiogenesis. Black tea contains the highest concentrations of theaflavins. (NCI04)]
Thiouracil	NCIT_C29856	[A sulfur-containing uracil. An established antithyroid drug and highly selective inhibitor of nitric oxide synthase (NOS), thiouracil also covalently binds to dopaquinone, produced by tyrosinase catalyzed oxidation of tyrosine, thereby selectively accumulating in de novo-synthesized melanin in overactive melanin-producing cells and providing a means to localize melanoma cells. (NCI04)]
Nitric Oxide Synthase Inhibitor	NCIT_C29574	[Any substance that inhibits nitric oxide synthase, an enzyme that catalyzes the production of nitric oxide from L-arginine. Nitric oxide is an important intercellular signaling molecule and inhibition of nitric oxide synthase effects many wide-ranging body processes and systems.]
Cresidine	NCIT_C29847	[A white, crystalline aromatic amine that is soluble in organic solvents and emits toxic fumes of nitrogen oxides when heated to decomposition. p-Cresidine is exclusively used as a chemical intermediate in the manufacture of dyes. p-Cresidine is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)]
Grade 5 Oral Hemorrhage, CTCAE	NCIT_C146458