Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Grade 5 Mucosal Infection, CTCAE	NCIT_C146446	[Death]
Double Blind Study	NCIT_C15228	[A study method in which neither the subjects nor the investigators are permitted to know which subject is receiving which treatment.]
Antitumor Drug Screening Assay	NCIT_C15229	[A technique used for assessment of the effectiveness of a potential antineoplastic agent.]
Pharmacological Study	NCIT_C62674
Juvenile Type Ovarian Granulosa Cell Tumor	NCIT_C7289	[A granulosa cell tumor that affects females in the first three decades of life. In young girls it may present with pseudoprecocity. In women during reproductive years, it may present with menstrual abnormalities.]
Ovarian Granulosa Cell Tumor	NCIT_C6261	[A granulosa-stromal cell tumor that arises from the ovary. It is characterized by the presence of granulosa cells that comprise at least ten percent of the cellular population. The granulosa cells are often found in a background that contains theca and fibrous cells. There are two major subtypes recognized, adult and juvenile granulosa cell tumor. Clinically, patients may present with an abdominal mass. Symptoms depend on the patient's age. The most important indicator of prognosis is tumor stage. Age over forty years at the time of the initial diagnosis, large tumor size, bilaterality, cellular atypia, and increased mitotic activity are factors indicating a potentially aggressive clinical course and relative poor prognosis.]
Juvenile Type Granulosa Cell Tumor	NCIT_C4207	[A granulosa cell tumor occurring in the ovary and testis. In females it occurs predominantly in the first three decades of life and presents unilaterally as stage I disease in the vast majority of cases. It is characterized by the presence of granulosa cells forming macrofollicular structures. The majority of cases have a good prognosis. In males it represents the most frequent congenital testicular neoplasm and the vast majority of cases occur in the perinatal period. It presents as a scrotal or abdominal mass and it more often affects the left testis. Approximately 20% of the patients have ambiguous external genitalia. It is characterized by the presence of cystic spaces lined by granulosa cells and cells resembling theca cells. Metastases have not been reported.]
PDZ and LIM Domain Protein 4	NCIT_C29870	[PDZ and LIM domain protein 4 (330 aa, ~35 kDa) is encoded by the human PDLIM4 gene. This protein may play a role in bone development.]
PDZ Domain	NCIT_C133734	[A globular protein domain of 80 to 90 amino acids comprising six beta-strands and two alpha-helices that plays a role in anchoring receptor proteins in the membrane to cytoskeletal components.]
LIM Domain	NCIT_C13672	[The LIM domain is a zinc binding, cysteine rich motif consisting of two tandemly repeated zinc fingers. Unlike GATA type zinc fingers, LIM domains do not bind DNA but instead mediate protein-protein interactions. Functionally, LIM domain containing proteins have been implicated in cell lineage specification, cytoskeletal organization, and organ development.]
PDLIM4 Gene	NCIT_C24740	[This gene plays a role in cytoskeletal modeling via regulation of actin fiber turnover.]
Black Tea	NCIT_C29871	[Black tea is an infusion of dried leaves from plants of the Theaceae family. Due to the alkaloid caffeine, its main effect is stimulation. Black teas also contain other phytochemicals such as flavonoid and flavonoid-related compounds with strong antioxidant effects. They also attenuate atherosclerotic inflammation, reduce thrombosis, promote normal endothelial function, and block expression of cellular adhesion molecules. Black tea may reduce the risk of cancer, heart diseases, infectious diseases, and degenerative diseases. (NCI04)]
Receptor-Interacting Serine/Threonine-Protein Kinase 2	NCIT_C29872	[Receptor-interacting serine/threonine-protein kinase 2 (540 aa, ~61 kDa) is encoded by the human RIPK2 gene. This protein is involved in protein phosphorylation, apoptosis and inflammation.]
Receptor-Interacting Serine/Threonine-Protein Kinase 3	NCIT_C29873	[Receptor-interacting serine/threonine-protein kinase 3 (518 aa, ~57 kDa) is encoded by the human RIPK3 gene. This protein plays a role in the induction of necrosis.]
RING Finger Protein 11	NCIT_C29874	[RING finger protein 11 (154 aa, ~17 kDa) is encoded by the human RNF11 gene. This protein plays a role in protein ubiquitination and degradation.]
RNA, Ribosomal 1	NCIT_C29875	[Encoded by human RNR1 Gene, RNA Ribosomal 1 is a ribosomal RNA associated with proteins as structural components of a ribosome where polypeptides are produced by interacting with tRNA and mRNA. (From NCI)]
Ribosomal RNA	NCIT_C814	[An RNA molecule that does not contain protein-coding sequence information and constitutes the majority of the cellular RNA (~80%). This nucleic acid associates with multiple proteins to form ribosomes, which are the organelles that drive mRNA-directed protein synthesis.]
Ribonuclease 3	NCIT_C29876	[Ribonuclease 3 (1374 aa, ~159 kDa) is encoded by the human DROSHA gene. This protein is involved in microRNA biogenesis.]
Endoribonuclease	NCIT_C25959	[A hydrolase enzyme which makes oligonucleotides and polynucleotides by hydrolysing the interior bonds of ribonucleotides.]
Rho-Associated Protein Kinase 1	NCIT_C29877	[Rho-associated protein kinase 1 (1354 aa, ~158 kDa) is encoded by the human ROCK1 gene. This protein is involved in both the propagation of Rho signaling and protein phosphorylation.]