Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Grade 4 Pericardial Effusion, CTCAE	NCIT_C146037	[Life-threatening consequences; urgent intervention indicated]
Grade 4 Pericardial Tamponade, CTCAE	NCIT_C146038	[Life-threatening consequences; urgent intervention indicated]
Grade 4 Periorbital Infection, CTCAE	NCIT_C146039	[Life-threatening consequences; urgent intervention indicated]
Vascular Disrupting Agent BNC105P	NCIT_C88338	[A benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.]
Tubulin Binding Agent	NCIT_C25974	[Any agent that binds to tubulin molecules and interferes with the microtubule assembly and disassembly dynamic. A tubulin binding agent impedes cell division and can be used to treat a variety of cancers.]
Carbon C-14 Dacomitinib	NCIT_C88339	[A radioconjugate consisting of an orally bioavailable small-molecule inhibitor of the epidermal growth factor receptor (erbB or HER) family of tyrosine kinases radiolabeled with carbon-14 with potential antineoplastic and beta-emitting radioisotope activity. PF-00299804 specifically and irreversibly binds to and inhibits human Her-1, Her-2, and Her-4, resulting in the proliferation inhibition and apoptosis of tumor cells that overexpress these receptors. The HER receptor family of tyrosine kinases, often overexpressed by a variety of tumor cell types, may contribute to tumor cell proliferation, differentiation, migration, and survival. PF-00299804 radiolabeled with carbon C-14 may be used as a radiotracer in pharmacological studies of PF-00299804 metabolism.]
Non-Adjuvanted A(H1N1) Influenza Vaccine	NCIT_C88334	[A monovalent vaccine containing hemagglutinin (HA) of influenza A (H1N1)-like virus with potential immunomodulating activity. Upon administration, non-adjuvanted A(H1N1) influenza vaccine may stimulate the immune system to mount an antibody response against H1N1.]
Archexin	NCIT_C88335	[A 20-mer antisense oligodeoxynucleotide (ODN) against the proto-oncogene Akt with potential antineoplastic activity. Akt-1 antisense oligonucleotide RX-0201 binds to Akt-1 mRNA, inhibiting translation of the transcript; suppression of Akt-1 expression may result in the inhibition of cellular proliferation and the induction of apoptosis in tumor cells that overexpress Akt-1. Akt-1 is a serine-threonine protein kinase that stimulates proliferation and inhibits apoptosis of tumor cells.]
Holmium Ho 166 Poly(L-Lactic Acid) Microspheres	NCIT_C88336	[Holmium Ho166 containing poly l-lactic acid (PLA) microspheres with potential antineoplastic actvity. Upon intra-arterial hepatic administration of holmium 166 microspheres, this agent is able to emit both beta particles direct killing cells and gamma photons for nuclear imaging. In addition, since holmium 166 is paramagnetic, this agent can be used for magnetic resonance imaging (MRI).]
Smoothened Antagonist LDE225 Topical	NCIT_C88337	[A topical formulation of the small-molecule Smoothened (Smo) antagonist LDE225 with potential antineoplastic activity. Upon topical application, smoothened antagonist LDE225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo.]
Smoothened Antagonist	NCIT_C155725	[Any agent that is an antagonist at the Smoothened (SMO) receptor.]
Breast Hemangiopericytoma	NCIT_C40396	[A hemangiopericytoma arising from the breast.]
Hemangiopericytoma	NCIT_C3087	[An antiquated term that refers to benign or malignant mesenchymal neoplasms characterized by the presence of neoplastic spindle-shaped to round cells arranged around thin-walled branching vascular spaces.]
Breast Myofibroblastoma	NCIT_C40397	[A myofibroblastoma occurring in the breast of both women and men. It presents as a slowly growing mass.]
Breast Soft Tissue Neoplasm	NCIT_C40406	[A benign or malignant mesenchymal neoplasm of the breast. Representative examples of benign mesenchymal neoplasms include leiomyoma, lipoma, and myofibroblastoma. Representative examples of malignant mesenchymal neoplasms include angiosarcoma, leiomyosarcoma, and liposarcoma.]
Breast Inflammatory Myofibroblastic Tumor	NCIT_C40398	[A multinodular intermediate fibroblastic neoplasm arising from the breast. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells.]
Breast Leiomyoma	NCIT_C40399	[A well-circumscribed benign smooth muscle neoplasm arising from the breast. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.]
3'-Aminomethyl Nicotine-P. aeruginosa r-Exoprotein A Conjugate Vaccine	NCIT_C88341	[A hapten-carrier immunoconjugate composed of the hapten trans-3'-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is not immunogenic, must be haptenized and conjugated to a carrier protein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminium hydroxide may be used as an adjuvant for this vaccine.]
CpG Oligodeoxynucleotide GNKG168	NCIT_C88342	[A synthetic, 21-mer, unmethylated CpG motif-based oligodeoxynucleotide (ODN), with immunostimulatory activity. CpG oligodeoxynucleotide GNKG168 binds to and activates Toll-like receptor 9 (TLR9) and is taken up into cells by endocytosis; once internalized, it may activate numerous signaling transduction pathways resulting in the release of multiple cytokines, such as immunoglobulins (Igs), interferons (IFNs), interleukins (ILs) and tumor necrosis factor (TNF). Through activation of TLR9, this ODN can directly stimulate B-lymphocytes, dendritic and natural killer (NK) cells, resulting in an increase in innate immunity and antibody-dependent cellular cytotoxicity (ADCC). In addition, through the release of IL-12 and IFN, this agent may induce a preferential shift to the T-helper 1(Th1) phenotype resulting in enhanced CD8+ T cell-mediated antitumor cytotoxicity.]
Tetraphenyl Chlorin Disulfonate	NCIT_C88344	[A meso-tetraphenylchlorin substituted by two adjacent sulfonated groups with potential photosensitizing activity. Upon administration, tetraphenyl chlorin disulfonate incorporates into the cell's endosome and lysosome membranes. Subsequently, cytotoxic agents are administered and accumulate in endosomal and lysosomal compartments; upon local activation by light, tetraphenyl chlorin disulfonate produces reactive oxygen species (ROS), such as singlet oxygen, damaging endo/lysosomal membranes and accumulated cytotoxic agents are released into the tumor cell cytosol. This photochemical internalization (PCI) method can enhance the efficacy and selectivity of cytotoxic agents.]