Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Antibody-Drug Conjugate BAY79-4620	NCIT_C88332
Gamma-Secretase Inhibitor RO4929097	NCIT_C88333	[An orally bioavailable, small-molecule gamma secretase (GS) inhibitorwith potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth.]
CDC7 Kinase Inhibitor NMS-1116354	NCIT_C88316	[An orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor NMS-1116354 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 initiates DNA replication by phosphorylating MCM2 (minichromosome maintenance complex component 2) at Ser40 and Ser53.]
SGRQ Past 4 Weeks Version - Respiratory Problems a Nuisance to Family	NCIT_C112703	[St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are questions about other effects that your respiratory problems may have on you these days: My respiratory problems are a nuisance to my family, friends or neighbors.]
HER2Bi-Armed Activated T Cells	NCIT_C88317	[Activated T cells (ATC) that have been coated with bispecific antibodies (BiAb), with potential antineoplastic and immunomodulating activities. In vitro, T cells are activated through exposure to the anti-CD3 murine monoclonal antibody OKT3 and interleukin 2 for 14 days and then armed with anti-CD3 x anti-Her2 bispecific antibody (Her2Bi). Upon administration, HER2Bi-armed activated T cells attach to CD3-expressing T cells and HER2/neu-expressing tumor cells, selectively cross-linking T cells and tumor cells; this may result in the recruitment and activation of cytotoxic T lymphocyte (CTLs), CTL perforin-mediated tumor cell cytolysis, and the secretion of antitumor cytokines and chemokines.]
SGRQ Past 4 Weeks Version - Get Afraid When Cannot Catch My Breath	NCIT_C112704	[St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are questions about other effects that your respiratory problems may have on you these days: I get afraid or panic when I cannot catch my breath.]
Canerpaturev	NCIT_C88318	[A non-engineered, naturally oncolytic, replication-competent spontaneous herpes simplex virus (HSV) type I mutant variant. Upon intratumoral injection, canerpaturev transfects, replicates in, and lyses rapidly dividing cells such as tumor cells. In addition, this agent may increase host immune responses that may kill non-infected tumor cells.]
SGRQ Past 4 Weeks Version - Not in Control of My Respiratory Problems	NCIT_C112705	[St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are questions about other effects that your respiratory problems may have on you these days: I feel that I am not in control of my respiratory problems.]
Iodine I-123 ADAM	NCIT_C88319	[A radiopharmaceutical containing the serotonin transporter (SERT) ligand ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine] labeled with the radioisotope iodine I 123, with SERT-binding and radioisotope activities. Upon administration, iodine I 123 ADAM selectively binds to SERT-expressing cells; subsequently, SERT-expressing tissues may be visualized using single photon emission computed tomography (SPECT). SERT is a monamine transporter protein found in the membranes of neurons and platelets; in neurons it transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons, terminating serotonin's function.]
SGRQ Past 4 Weeks Version - Not Expect Respiratory Problems Get Better	NCIT_C112706	[St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are questions about other effects that your respiratory problems may have on you these days: I do not expect my respiratory problems to get any better.]
Milciclib Maleate	NCIT_C88312	[The maleate salt form of milciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and tropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types.]
Polo-like Kinase 1 Inhibitor NMS-1286937	NCIT_C88313	[An orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.]
SGRQ Past 4 Weeks Version - Coughing Disturbs My Sleep	NCIT_C112700	[St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are more questions about your cough and shortness of breath these days: My coughing or breathing disturbs my sleep.]
Tepotinib	NCIT_C88314	[An inhibitor of MET tyrosine kinase with potential antineoplastic activity. Tepotinib selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase. The receptor tyrosine kinase MET (also known as hepatocyte growth factor receptor or HGFR), is the product of the proto-oncogene c-Met and is overexpressed or mutated in many tumor cell types; this protein plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis.]
SGRQ Past 4 Weeks Version - I Get Exhausted Easily	NCIT_C112701	[St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are more questions about your cough and shortness of breath these days: I get exhausted easily.]
Vorsetzumab Mafodotin	NCIT_C88315	[An antibody-drug conjugate (ADC) consisting of a humanized monoclonal antibody, directed against the extracellular domain of the human CD70 molecule, conjugated to the auristatin analogue monomethyl auristatin phenylalanine (MMAF), with potential antineoplastic activity. The anti-CD70 antibody moiety of vorsetuzumab mafodotin selectively binds to the extracellular domain of CD70 on tumor cell surfaces. Upon internalization, the MMAF moiety is released, binds to tubulin and inhibits its polymerization, which may result in G2/M phase arrest, tumor cell apoptosis and inhibition of cellular proliferation in tumor cells that overexpress CD70. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells.]
SGRQ Past 4 Weeks Version - My Cough is Embarrassing in Public	NCIT_C112702	[St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are questions about other effects that your respiratory problems may have on you these days: My cough or breathing is embarrassing in public.]
AS03-Adjuvanted H1N1 Pandemic Influenza Vaccine	NCIT_C88320	[A split-virus, inactivated influenza A (H1N1) vaccine containing H1N1 immunizing antigen combined with the adjuvant AS03, with potential immunostimulating activity. Upon intramuscular vaccination, AS03-adjuvanted H1N1 influenza vaccine may elicit an immune response against the H1N1 virus and the production of anti-H1N1 antibodies. AS03 is a stabilized oil-in-water emulsion adjuvant containing DL-alpha-tocopherol, squalene and polysorbate 80 that non-specifically stimulates cell-mediated immune antigen responses.]
Fumagillin-Derived Polymer Conjugate XMT-1107	NCIT_C88321	[A polymeric prodrug consisting of the fumagillol-derived small molecule XMT-1191 tethered to the hydrophilic, biodegradable70 kDa polymer poly[1-hydroxymethylethylene hydroxymethylformal] (PHF) with potential antiangiogenic and antineoplastic activities. Upon administration, fumagillin-derived polymer conjugate XMT-1107 releases XMT-1191, which may inhibit angiogenesis through the irreversible inhibition of the methionine aminopeptidase 2 (METAP2); although the exact mechanism of action has yet to be fully elucidated, this agent appears to induce cell cycle arrest in endothelial cells, inhibiting their proliferation and migration. Compared to an unconjugated fumagillin analog, XMT-1107 exhibits improved solubility and an extended half life due to its PHF backbone. METAP2, a member of the methionyl aminopeptidase family, binds two cobalt or manganese ions and protects the alpha subunit of eukaryotic initiation factor 2 (EIF2) from inhibitory phosphorylation by removing the amino-terminal methionine residue from nascent protein; this aminopeptidase may be overexpressed in a variety of tumor cell types.]
Docetaxel Formulation CKD-810	NCIT_C88322	[An injectable formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response.]