Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
TERF2IP wt Allele	NCIT_C112897	[Human TERF2IP wild-type allele is located in the vicinity of 16q23.1 and is approximately 113 kb in length. This allele, which encodes telomeric repeat-binding factor 2-interacting protein 1, plays a role in both the regulation of gene expression and the modulation of telomere recombination.]
TERF2IP Gene	NCIT_C112896	[This gene is involved in both telomere maintenance and gene transcription.]
Telomerase Regulation Pathway	NCIT_C91664
16q23.1	NCIT_C13858	[A chromosome band present on 16q]
Telomeric Repeat-Binding Factor 2-Interacting Protein 1	NCIT_C112898	[Telomeric repeat-binding factor 2-interacting protein 1 (399 aa, ~44 kDa) is encoded by the human TERF2IP gene. This protein is involved in both the negative regulation of telomere recombination and the modulation of gene transcription.]
Ovarian Small Cell Carcinoma, Pulmonary Type	NCIT_C40440	[An aggressive small cell neuroendocrine carcinoma that arises from the ovary. Morphologically, it resembles the small cell carcinoma that arises from the lung.]
Ovarian Neuroendocrine Neoplasm	NCIT_C5237	[An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma.]
BACE1 Gene	NCIT_C112893	[This gene plays a role in protein cleavage.]
Protein Cleavage	NCIT_C41598	[Protein Cleavage involves hydrolysis by proteolytic enzymes of specific peptide bond(s), forming smaller polypeptides in the target protein during maturation or modification of functional activity.]
BACE1 wt Allele	NCIT_C112894	[Human BACE1 wild-type allele is located within 11q23.2-q23.3 and is approximately 31 kb in length. This allele, which encodes beta-secretase 1 protein, is involved in proteolytic processing.]
Gestational Ovarian Choriocarcinoma	NCIT_C40442	[A rare malignant trophoblastic tumor that arises from the ovary as a result of ectopic ovarian pregnancy. There is no germ cell component present.]
Gestational Choriocarcinoma	NCIT_C4646	[A rare, highly malignant epithelial tumor that develops from a hydatidiform mole (50%), following abortion (25%), or during normal pregnancy (22%). It is characterized by the presence of invasive and anaplastic trophoblastic tissue composed of intermediate trophoblastic cells, cytotrophoblasts and syncytiotrophoblasts, abundant vascularity, and secretion of human chorionic gonadotropin. Because of rapid growth and a high propensity for hemorrhage, this neoplasm often constitutes a medical emergency.]
Ovarian Choriocarcinoma	NCIT_C4515	[A choriocarcinoma arising from the ovary. When it appears before puberty is of germ cell origin. In children and young adults signs and symptoms include precocious pseudopuberty and vaginal bleeding. Serum human chorionic gonadotropin is elevated. Germ cell derived ovarian choriocarcinoma should be differentiated from primary or metastatic gestational choriocarcinoma affecting the ovary. The prognosis of germ cell derived choriocarcinoma is less favorable and requires more aggressive chemotherapy treatment regimens compared to gestational choriocarcinoma.]
Beta-Secretase 1	NCIT_C112895	[Beta-secretase 1 (501 aa, ~56 kDa) is encoded by the human BACE1 gene. This protein plays a role in the proteolysis of ectodomains of membrane proteins.]
Ovarian Wilms Tumor	NCIT_C40443	[An embryonal neoplasm arising from the ovary with morphologic features resembling Wilms tumor of the kidney. It occurs during the reproductive age and may present as a rapidly growing adnexal mass.]
Ovarian Malignant Mesothelioma	NCIT_C40444	[A rare malignant mesothelial neoplasm that usually involves both the ovarian surface and the ovarian stroma. In most cases there is bilateral ovarian involvement.]
Leuteoma of Pregnancy	NCIT_C40445	[A non-neoplastic and self-limited condition that occurs during pregnancy. It is characterized by proliferation of luteinized stromal cells that replace the normal ovarian stromal cells. It is usually manifested with bilateral multinodular ovarian masses. Treatment is not required.]
BACE2 Gene	NCIT_C112890	[This gene is involved in proteolytic processing.]
Ovarian Stromal Hyperthecosis	NCIT_C40446	[A non-neoplastic disorder that usually affects postmenopausal women. It is characterized by the leuteinization of ovarian stromal cells. The ovaries are bilaterally involved and enlarged. When it affects women in reproductive age, it causes virilization, high blood pressure, and increased insulin levels.]
BACE2 wt Allele	NCIT_C112891	[Human BACE2 wild-type allele is located in the vicinity of 21q22.3 and is approximately 108 kb in length. This allele, which encodes beta-secretase 2 protein, plays a role in protein cleavage.]