Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Unit of Diffusion Coefficient	NCIT_C68743	[A unit of factor of proportionality representing the amount of substance diffusing across a unit area through a unit concentration gradient in unit time.]
MART-1/gp100/Tyrosinase/MAGE-A3 Peptides-loaded Irradiated Allogeneic Plasmacytoid Dendritic Cells	NCIT_C107159	[Irradiated allogeneic, HLA-A0201 positive, plasmacytoid dendritic cells (pDCs) loaded with 4 melanoma peptides derived from the tumor associated antigens (TAAs) MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3, with potential immunostimulating and antineoplastic activities. Upon subcutaneous administration, the irradiated allogeneic pDCs may trigger functional multi-specific T cells from peripheral blood mononuclear cells and tumor-infiltrating lymphocytes, and activate the immune system to mount a cytotoxic T-lymphocyte response against HLA-A0201 positive melanoma cancer cells expressing the TAAs MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3. These TAAs are upregulated in a variety of tumor cells. The pDCs are derived from a distinct subset of dendritic cells (DCs) with a plasma cell-like morphology and express a characteristic set of surface markers and may increase the anti-tumor immune responses.]
Biot	NCIT_C68907	[A CGS unit of electric current equal to 10 ampere.]
Unit of Electric Current	NCIT_C67323
Ampere per Square Meter	NCIT_C68908	[A SI derived unit of an electric current density which is equal to an electric current of one ampere circulating in a homogeneous conductor with a cross section area of one square meter.]
Unit of Electric Current Density	NCIT_C68745	[A unit for measurement of magnitude of the electrical current per cross-sectional area.]
Volt per Meter	NCIT_C68909	[A SI derived unit of electric field strength defined as the strength that exerts the force equal to one newton on an electric point charge of one coulomb.]
Unit of Electric Field Strength	NCIT_C68746	[A unit of the force, exerted by electric field on an electric point charge.]
PSMA Peptide	NCIT_C29340	[A peptide based on HLA-A*0201 restricted peptides of the prostate-specific membrane antigen (PSMA). Prostate epithelial cells express PSMA and overexpression has been detected in hormone refractory prostate carcinoma. Autologous dendritic cells are used to deliver the peptides to the patient. Recombinant PSMA peptide may trigger a cytotoxic T-cell response to prostate cancer cells.]
Vaccine Antigen	NCIT_C2835	[A vaccine component consisting of a protein, small peptide, or polysaccharide, natural or synthetic, that once administered is bound by antibody, thereby inducing mechanisms of antibody-dependent cell-mediated cytotoxicity (ADCC). In cancer immunotherapy, a cancer vaccine containing specific tumor-associated antigens (TAAs) may be used to boost an immune response against a tumor expressing those TAAs. (NCI04)]
Talotrexin	NCIT_C29341	[An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.]
Dihydrofolate Reductase	NCIT_C17191	[Dihydrofolate reductase (187 aa, ~21 kDa) is encoded by the human DHFR gene. This protein is involved in folate metabolism and the synthesis of nucleotides and glycine.]
PTF	NCIT_C29342
Pyran Polymer	NCIT_C29343	[A hydrocarbon-based polymer containing a pyran nucleus used to bioconjugate various drugs,. Use of a pyran polymer-drug bioconjugate may alter the biodistribution of a low molecular weight drug, resulting in disease-specific targeting with reduced drug access to sites of toxicity such as the bone marrow; the large size of the bioconjugate does not allow the active agent to pass the blood-bone marrow barrier. (NCI04)]
Imidazole-Pyrazole	NCIT_C29344	[A synthetic agent, also known as IMPY, with antineoplastic properties. IMPY inhibits ribonucleotide reductase, an enzyme that converts ribonucleotides to deoxyribonucleotides during DNA synthesis; this agent specifically binds the smaller, nonheme-iron subunit of the enzyme. (NCI04)]
Left Ventricular Systolic Dysfunction, CTCAE 5.0	NCIT_C146719	[A disorder characterized by failure of the left ventricle to produce adequate output.]
Pancrelipase	NCIT_C29345	[A standardized enzyme concentrate containing the pancreatic enzymes, lipase, protease and amylase used in enzyme substitution therapy. Lipase, protease and amylase break down fat, protein, and starches, respectively in the small intestine, thereby promoting digestion. Pancrelipase is used to reduce malabsorption when the pancreas is unable to secrete sufficient amounts of these enzymes.]
Pantoprazole	NCIT_C29346	[A substituted benzimidazole and proton pump inhibitor with antacid activity. Pantoprazole is a lipophilic weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulphenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.]
Cytochrome P450 2C19	NCIT_C25948	[Cytochrome P450 2C19 (490 aa, ~56 kDa) is encoded by the human CYP2C19 gene. This protein is involved in steroid, terpenoid and drug metabolism.]
Million Colony Forming Units per Gram	NCIT_C68900	[A derived unit of viable cell concentration defined as the number of million colony forming units (10E6 CFU) in one gram of substance.]