Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Organic Anion Transporter Protein	NCIT_C107150	[A family of transmembrane proteins that play a role in the transport of organic anions including bile acids and bilirubin.]
Histone H3 Dimethyl Lys27	NCIT_C107151	[A post-translationally modified form of histone H3 where the lysine residue at position 27 is dimethylated. This modification may be a marker for transcriptional repression.]
Histone H3 Dimethyl Lys4	NCIT_C107152	[A post-translationally modified form of histone H3 where the lysine residue at position 4 is dimethylated. This modification may be a marker for transcriptionally active genes.]
Histone H3 Trimethyl Lys4	NCIT_C107153	[A post-translationally modified form of histone H3 where the lysine residue at position 4 is trimethylated. This modification may be a marker for areas of active gene expression.]
EGFR NP_005219.2:p.G719X	NCIT_C107154	[A change in the amino acid residue at position 719 in the epidermal growth factor receptor protein where glycine has been replaced by another amino acid.]
EGFR Protein Variant	NCIT_C98356	[A variation in the amino acid sequence for the epidermal growth factor receptor protein.]
EGFR Exon 18 Mutation	NCIT_C128661	[A molecular genetic abnormality indicating the presence of a mutation in exon 18 of the EGFR gene.]
Androstanedione	NCIT_C107155	[A steroid hormone that is a mixture of alpha and beta isomers, which have different orientations for the hydrogen group at position 5. 5alpha-androstanedione is a metabolic precursor for both testosterone and estrone.]
Steroid Hormone	NCIT_C2289	[Hormones possessing the steroid ring system; e.g., androgens, estrogens, adrenocortical hormones.]
Fosnetupitant/Palonosetron Hydrochloride	NCIT_C146720	[A combination formulation containing the prodrug of netupitant, fosnetupitant, a selective neurokinin 1 receptor (NK1R; TACR1) antagonist, and the hydrochloride salt form of palonosetron, a selective serotonin (5-hydroxytrytamine; 5-HT) receptor subtype 3 (5-HT3R) antagonist, with potential antiemetic activity. Upon intravenous administration, fosnetupitant is converted by phosphatases to its active form netupitant. Netupitant competitively binds to and blocks the activity of NK1Rs in the central nervous system (CNS), by inhibiting binding of the endogenous tachykinin-derived neuropeptide substance P (SP) to NK1R. This prevents delayed emesis, which is associated with SP secretion. Palonosetron competitively blocks the interaction of 5-HT with 5-HT3Rs located on vagal afferent nerves in the chemoreceptor trigger zone (CTZ). This inhibits acute emesis associated with 5-HT secretion and subsequent 5-HT3R activation. Altogether, this results in inhibition of acute and delayed nausea and vomiting, and may prevent chemotherapy-induced nausea and vomiting (CINV).]
NCCN Guidelines Distress Management Distress Thermometer Screening Tool Version 1.2011	NCIT_C107156	[A single-item question screening tool developed by the National Comprehensive Cancer Network (NCCN) Distress Management Panel used to identify patient distress coming from any source.]
Index Date	NCIT_C146721	[A date used as a reference point for ensuing events, often a diagnosis date, or a first visit date, or the date a patient enrolled in a study.]
NCCN Guidelines Distress Management Problem List Screening Tool Version 1.2011	NCIT_C107157	[A screening tool developed by the National Comprehensive Cancer Network (NCCN) Distress Management Panel used to identify patient problems in five categories.]
Weber per Meter	NCIT_C68916	[A SI unit of magnetic vector potential.]
Unit of Magnetic Vector Potential	NCIT_C68798
Glutathione S-Transferase Alpha	NCIT_C107147	[A homo- or heterodimeric form of the glutathione S-transferase enzyme that is comprised of two alpha family subunits.]
Glutathione S-Transferase	NCIT_C16641	[A class of enzymes that catalyze the reaction of glutathione with an acceptor molecule (an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway.]
Oersted	NCIT_C68917	[A CGS unit of magnetic field strength in a dielectric equal to Gauss multiplied by the number inverse to the magnetic permeability, or as the field strength in a vacuum at a distance one centimeter from a unit magnetic pole.]
Unit of Magnetic Field Strength	NCIT_C68795	[A unit of magnetic field strength.]
Glutathione S-Transferase Mu	NCIT_C107148	[A homo- or heterodimeric form of the glutathione S-transferase enzyme that is comprised of two mu family subunits.]