Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Pramipexole Dihydrochloride | NCIT_C29374 | [The hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain. Compared to other dopamine agonists, the use of this agent may be associated with fewer dyskinetic side effects in treated subjects. (NCI04)] |
| Pravastatin Sodium | NCIT_C29375 | [The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.] |
| HMG-CoA Reductase Inhibitor | NCIT_C1655 | [Any substance that inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. Inhibition of HMG-CoA reductase acts to lower plasma cholesterol and lipoprotein levels.] |
| MCTS1 wt Allele | NCIT_C54310 | [Human MCTS1 wild-type allele is located within Xq22-q24 and is approximately 8 kb in length. This allele, which encodes multiple copies in a T-cell malignancy protein, plays a role in cell cycle deregulation, inhibition of apoptosis and promotion of angiogenesis.] |
| MCTS1 Gene | NCIT_C24588 | [This gene plays a role in the positive regulation of cell growth and proliferation.] |
| Etoposide/Prednisone | NCIT_C29376 | |
| Etoposide | NCIT_C491 | [A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04)] |
| Prednisone | NCIT_C770 | [A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations.] |
| Gel with Applicator | NCIT_C68974 | |
| Conjugated Estrogen/Medroxyprogesterone-containing Formulation | NCIT_C29377 | [A combination preparation of conjugated estrogens, including sodium estrone sulfate, sodium equilin sulfate, and the progestin medroxyprogesterone acetate. The conjugated estrogens increase the diminishing levels of estrogen in menopausal and postmenopausal women. Maintaining adequate estrogen levels decreases symptoms such as hot flashes, night sweats, irregular menstruation, fat redistribution, mood swings, sleep disorders, vaginal dryness and osteoporosis. Medroxyprogesterone acetate is added to prevent endometrial proliferation and a subsequent elevated risk of estrogen-induced endometrial cancer.] |
| Gel with Pre-Filled Applicator | NCIT_C68975 | |
| Anti-hemorrhoidal Formulation | NCIT_C29378 | [A brand of combination medications, by Wyeth Pharmaceuticals, used in the treatment of hemorrhoids. Preparation H is used to relieve pain, swelling and pruritis, as well as, to soothe and protect the hemorrhoidal tissue. Preparation H products are formulated as a cream, ointment, cooling gel, suppositories and witch hazel wipes.] |
| Jelly with Applicator | NCIT_C68976 | |
| Probenecid/Colchicine | NCIT_C29379 | [A combination of probenecid and colchicine with antihyperuricemic activity. Probenecid, a benzoic acid derivative, competitively inhibits the reabsorption of urate at the proximal tubule in the kidney, thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. Colchicine is a natural alkaloid with anti-gout and anti-inflammatory properties. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis leading to an inhibition of leukocyte migration and reduction of the inflammatory response to deposited urate crystals. This agent also interrupts monosodium urate crystal deposition in joint tissues, thereby preventing the resultant inflammatory response.] |
| Cream with Pre-Filled Applicator | NCIT_C68977 | |
| Cream with Applicator | NCIT_C68978 | |
| Ointment with Applicator | NCIT_C68979 | |
| MCAM wt Allele | NCIT_C54308 | [Human MCAM wild-type allele is located in the vicinity of 11q23.3 and is approximately 9 kb in length. This allele, which encodes cell surface glycoprotein MUC18 protein, plays a role in cellular adhesision, signal transduction and development.] |
| MCC wt Allele | NCIT_C54309 | [Human MCC wild-type allele is located in the vicinity of 5q21-q22 and is approximately 360 kb in length. This allele, which encodes colorectal mutant cancer protein, may play a role in tumor suppression. MCC wild-type allele is a candidate colorectal tumor suppressor gene.] |
| MCC Gene | NCIT_C17566 | [This gene plays a role in the negative regulation of cell cycle progression.] |