Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Polycarbophil/Carbomer/Glycerin/Palm Oil Glyceride/Mineral Oil-containing Vaginal Moisturizer | NCIT_C29414 | [A commercial combination preparation that contains an adhesive polycarbophil polymer, which is used for vaginal lubrication. Polycarbophil is an insoluble compound that absorbs water and, after topical administration, adheres to vaginal epithelial cells. As a result, it helps both moisturize vaginal tissue and relieve the discomfort that is associated with vaginal dryness.] |
| Percent Change From Baseline in Sum of Products of Perpendicular Diameter | NCIT_C132264 | [The most recently recorded sum of products of perpendicular diameters minus the baseline sum of products of perpendicular diameters divided by the baseline sum of products of perpendicular diameters, multiplied by 100.] |
| Murine MCA Ricin Conjugate | NCIT_C29415 | [An immunotoxin consisting of a murine monoclonal antibody (MCA) conjugated to the toxin ricin. The monoclonal antibody component binds to cell surface antigens, thereby targeting delivery of cytotoxic ricin to a specific cell type. The ricin component binds to cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)] |
| Ricin Immunoconjugate | NCIT_C2359 | [A ricin-containing immunotoxin with immunotherapeutic property. Ricin, a plant toxin extracted from castor beans, inhibits protein synthesis via cleaving ribosomal subunit 28S rRNA. Ricin immunoconjugate consists of specific antibody conjugated with the blocked ricin (bR), which has the galactose-binding sites of the B-chain blocked while leaving the ribosome-inactivating ricin A-chain intact, thereby attaining cell-type-specific immunotoxins.] |
| Percent Change From Nadir in Sum of Products of Perpendicular Diameters | NCIT_C132265 | [The most recently recorded sum of products of perpendicular diameters minus the lowest sum of diameters previously recorded divided by the lowest sum of products of perpendicular diameters previously recorded, multiplied by 100.] |
| Risperidone | NCIT_C29416 | [A benzisoxazole derivative with antipsychotic property. Risperidone selectively antagonizes serotonin (5-HT) effects via cortical 5-HT2 receptor, and, to a lesser extent, competes with dopamine at the limbic dopamine D2 receptor. The antagonism leads to decreased psychotic effects, such as hallucinations and delusions. In addition, risperidone has low to moderate affinity for histamine H1, 5-HT1A, 5-HT1C, and 5-HT1D receptors, while it has weak affinity for dopamine D1 and haloperidol-sensitive sigma site receptors.] |
| Anti-CD73 Monoclonal Antibody BMS-986179 | NCIT_C132266 | [A monoclonal antibody targeting the ectoenzyme 5'-ecto-nucleotidase (cluster of differentiation 73; CD73; 5'-NT; ecto-5'-nucleotidase; NT5E), with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD73 monoclonal antibody BMS-986179 targets and binds to CD73, leading to clustering and internalization of CD73. This prevents CD73-mediated conversion of extracellular adenosine monophosphate (AMP) to adenosine and decreases the amount of free adenosine. This prevents adenosine-mediated suppression of lymphocyte activity and increases the activity of CD8-positive effector cells. This also activates macrophages, and reduces the activity of both myeloid-derived suppressor cells (MDSCs) and regulatory T-lymphocytes. By abrogating the inhibitory effect on the immune system and enhancing the cytotoxic T-cell-mediated immune response against cancer cells, tumor cell growth is decreased. CD73, a plasma membrane protein belonging to the 5'-nucleotidase (NTase) family, is upregulated on a number of cancer cell types and catalyzes the conversion of extracellular nucleotides, such as AMP, to membrane-permeable nucleosides, such as adenosine; it plays a key role in adenosine-mediated immunosuppression within the tumor microenvironment.] |
| Sangivamycin Hydrochloride | NCIT_C29417 | [The salt of a deaza-adenosine antibiotic isolated from the bacterium Streptomyces rimosus with potent cytotoxic properties. Sangivamycin inhibits protein kinase C (PKC), a signaling mediator important for cell growth and differentiation. This agent may also interfere with protein synthesis by inhibiting the formation of complexes essential to the initiation of protein synthesis and DNA synthesis. (NCI04)] |
| Anti-GITR Agonistic Monoclonal Antibody BMS-986156 | NCIT_C132267 | [An anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR; tumor necrosis factor superfamily member 18; TNFRSF18; CD357) agonistic monoclonal antibody, with potential immune checkpoint modulating activity. Anti-GITR antibody BMS-986156 binds to and activates GITR, which is expressed on the cell surface of multiple types of T-cells. This stimulates the immune system, induces both the activation and proliferation of tumor antigen-specific T-effector cells (Teffs), and suppresses the function of activated T-regulatory cells (Tregs). This leads to tumor cell eradication. GITR, a member of the TNF receptor superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple immune cell types, including Tregs, Teffs, B-cells, and natural killer (NK) cells. Inappropriately activated Tregs suppress both Teffs and T-cell receptor (TCR) signaling.] |
| RTGF-Beta | NCIT_C29407 | |
| TP53 NM_000546.5:c.734G>A | NCIT_C146898 | [A nucleotide substitution at position 734 of the coding sequence of the TP53 gene where guanine has been mutated to adenine.] |
| TP53 Gene Mutation | NCIT_C118396 | [A change in the nucleotide sequence of the TP53 gene.] |
| TP53 NP_000537.3:p.G245D | NCIT_C146900 | [A change in the amino acid residue at position 245 in the cellular tumor antigen p53 protein where glycine has been replaced by aspartic acid.] |
| RV-B7 (RECOMB VACCINIA/B7) | NCIT_C29408 | |
| Trichothiodystrophy 4, Nonphotosensitive | NCIT_C146899 | [A subtype of trichothiodystrophy caused by mutation(s) in the MPLKIP gene, encoding M-phase-specific PLK1-interacting protein.] |
| Trichothiodystrophy | NCIT_C4924 | [A rare, autosomal recessive inherited syndrome characterized by brittle hair, mental and physical retardation, and decreased fertility.] |
| Recombinant Vaccinia-MUC1-B7 Vaccine | NCIT_C29409 | [An admixture of recombinant vaccinia virus encoding MUC-1 and recombinant vaccinia virus encoding the murine T-cell co-stimulatory molecule B7.1. MUC-1 is a glycosylated mucin that is overexpressed in breast, lung, pancreatic, prostate, stomach, colon, and ovarian carcinomas. Vaccination with MUC-1 in combination with B7.1 may enhance the cytotoxic T cell (CTL) immune response to tumors expressing MUC-1, compared to vaccination with MUC-1 alone. (NCI04)] |
| MUC-1 Peptide Vaccine | NCIT_C53290 | [A cancer vaccine comprised of a synthetic peptide derived from the mucin 1 (MUC1) antigen with potential antineoplastic activity. Upon administration, MUC1 peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the MUC1 antigen, resulting in decreased tumor growth. Overexpressed on many tumor cells, MUC1 antigen, a mammary-type apomucin, is a high-molecular-weight transmembrane glycoprotein.] |
| Carrot Seed Oil | NCIT_C107280 | [The oil extracted from the seeds of Daucus carota. Carrot seed oil is primarily used in skin treatment preparations.] |
| Cashew Oil | NCIT_C107281 | [The oil extracted from the nut fruit of Anacardium occidentale. Cashew oil is primarily used as a cooking oil.] |