Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Recombinant Human Bone Morphogenetic Protein 2	NCIT_C132249	[A recombinant form of human bone morphogenetic protein 2 (rhBMP-2), with potential bone remodeling and osteoinductive activities. Following administration, rhBMP-2 induces BMP-2 signaling cascades, which leads to osteoblast differentiation, enhancement of bone repair and formation, and improvement of re-vascularization. This promotes bone healing. BMP-2, a protein belonging to the transforming growth factor beta (TGFb) superfamily of proteins, plays a key role in bone and cartilage formation.]
Shared Anti-Idiotype-AB-S018	NCIT_C29430	[A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)]
Shared Anti-Idiotype-AB-S021A	NCIT_C29431	[A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)]
Shared Anti-Idiotype-AB-S024A	NCIT_C29432	[A murine monoclonal anti-idiotype antibody with potential antineoplastic activity. Shared anti-id-Ab-S024A binds to tumor-associated antigens (TAAs) on the surface of neoplastic cells resulting in tumor cell destruction by the reticuloendothelial system or cytotoxic T lymphocytes (CTL).]
Shared Anti-Idiotype-AB-S025	NCIT_C29433	[A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)]
Shared Anti-Idiotype-AB-S027	NCIT_C29434	[A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)]
LYPD3 Gene	NCIT_C132240	[This gene is involved in cell migration.]
DNA Minor Groove Binding Agent SG2000	NCIT_C29435	[A sequence-selective pyrrolobenzodiazepine (PBD) dimer with potential antineoplastic activity. Following intravenous administration, DNA minor groove binding agent SG2000 preferentially and covalently binds to purine-GATC-pyrimidine sequences, with the imine/carbinolamine moieties of SG2000 binding to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links and inhibits both DNA replication and gene transcription, which lead to the inhibition of cell growth. With a preference for binding to purine-GATC-pyrimidine sequences, SG2000 adducts do not appear to be susceptible to p53-mediated DNA excision repair.]
DNA Crosslinking Agent	NCIT_C25760	[An agent able to covalently bind to DNA causing inter- or intra-stranded cross-linking of DNA. The cross-linking results in misreading of the DNA code and inhibition of DNA synthesis. (NCI)]
DNA Minor Groove Binding Agent	NCIT_C2115	[An antineoplastic agent that either covalently or noncovalently binds to the minor groove of DNA, causing inhibition of DNA synthesis. (NCI)]
LYPD3 wt Allele	NCIT_C132241	[Human LYPD3 wild-type allele is located in the vicinity of 19q13.31 and is approximately 5 kb in length. This allele, which encodes Ly6/PLAUR domain-containing protein 3, plays a role in cell-matrix interactions.]
SPI-77	NCIT_C29436
Ly6/PLAUR Domain-Containing Protein 3	NCIT_C132242	[Ly6/PLAUR domain-containing protein 3 (346 aa, ~36 kDa) is encoded by the human LYPD3 gene. This protein is involved in cell-matrix interactions during cell migration.]
Outer Leaflet of the Lipid Bilayer	NCIT_C33234	[The extracellular facing lipid layer of the plasma membrane.]
SS1(dsFv) PE38	NCIT_C29437
LYPD3 Positive	NCIT_C132243	[Indicates that LYPD3 expression has been detected in a sample.]
STAMP	NCIT_C29438
FGFR Gene Fusion Positive	NCIT_C132244	[Indicates that the expression of a fusion containing FGFR family gene sequences has been detected in a sample.]
FGFR Family Alteration Positive	NCIT_C133705	[Indicates that mutation, overexpression or rearrangement of an FGFR family member has been detected in a sample.]
Genetic Finding	NCIT_C103223	[A laboratory test result that indicates the status of a molecular genetic or cytogenetic event in a pathologic process.]