Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Worst Severity Past Seven Days Ringing in Ears	NCIT_C132203	[A question about an individual's observation of the worst severity they have experienced related to ringing in their ears over the past seven days.]
Balsam Peru Oil	NCIT_C107269	[The essentail oil of Myroxylon balsamum. Balsam peru oil is used primarily in parfumery and skin care preparations.]
Sumatriptan Succinate	NCIT_C29470	[The succinate salt form of sumatriptan, a member of the triptan class of compounds with anti-migraine property. Sumatriptan succinate selectively binds to and activates serotonin 5-HT1 receptors. This results in constriction of meningeal, dural, cerebral or pial blood vessels via stimulation of the 5-HT1B receptors, thereby reducing the vascular pulsation and may provide relief in migraine headaches. Furthermore, agonistic action of this agent through presynaptic stimulation of 5-HT1D and/or 5-HT1F receptors prevents release of vasoactive and pro-inflammatory neuropeptide (calcitonin gene-related peptide), thereby may also relieve migraine headaches. In addition, central inhibition of pain transmission via the inhibition of trigeminal neurons in the brain stems and upper spinal cord mediated by 5-HT1B, 5-HT1D or 5-HT 1F receptors also aides in the alleviation of migraine pain.]
Worst Severity Past Seven Days Vaginal Dryness	NCIT_C132204	[A question about an individual's observation of the worst severity they have experienced related to vaginal dryness over the past seven days.]
Aminoglutethimide/Hydrocortisone/Suramin	NCIT_C29471
Suramin	NCIT_C853	[A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04)]
Cortisol	NCIT_C2290
Aminoglutethimide	NCIT_C233	[A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties. Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens. Aminoglutethimide does not suppress ovarian estrogen production.]
Worst Severity Past Seven Days Pain or Burning with Urination	NCIT_C132205	[A question about an individual's observation of the worst severity they have experienced related to pain or burning with urination over the past seven days.]
Flutamide/Hydrocortisone/Suramin	NCIT_C29472
Therapeutic Hydrocortisone	NCIT_C555	[A synthetic or semisynthetic analog of natural hydrocortisone hormone produced by the adrenal glands with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI04)]
Flutamide	NCIT_C509	[A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)]
Worst Severity Past Seven Days Difficulty Getting or Keeping an Erection	NCIT_C132206	[A question about an individual's observation of the worst severity they have experienced related to difficulty getting or keeping an erection over the past seven days.]
Swiss Kiss	NCIT_C29473
Worst Severity Past Seven Days Decreased Sexual Interest	NCIT_C132207	[A question about an individual's observation of the worst severity they have experienced related to decreased sexual interest over the past seven days.]
Transferrin Receptor-Targeted Liposomal p53 cDNA	NCIT_C29474	[A cationic liposomal, tumor-targeting p53 (TP53) gene delivery system with potential anti-tumor activity. Transferrin receptor-targeted liposomal p53 cDNA contains plasmid DNA encoding the tumor suppressor protein p53 packaged in membrane-like liposome capsules that are complexed with anti-transferrin receptor single-chain antibody (TfRscFv). Upon systemic administration, the anti-TfRscFv selectively binds to tumor cells expressing transferrin receptors. The p53 plasmid is delivered into the nucleus and as a result, p53 protein is produced in tumor cells that have altered p53 function. This results in the restoration of normal cell growth control mechanisms as well as normal response mechanisms to DNA damage.]
Worst Severity Past Seven Days Pain During Vaginal Sex	NCIT_C132208	[A question about an individual's observation of the worst severity they have experienced related to pain during vaginal sex over the past seven days.]
3'-C-ethynylcytidine	NCIT_C29475	[A synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. 3'-C-ethynylcytidine is metabolized in tumor cells to ethynylcytidine triphosphate (ECTP), which inhibits RNA synthesis by competitive inhibition of RNA polymerases I, II and III; subsequently, RNase L is activated, resulting in apoptosis. RNase L is a potent antiviral and antiproliferative endoribonuclease that cleaves singled stranded RNA, causes 28s rRNA fragmentation, and activates Janus Kinase (JAK), a mitochondrial-dependent apoptosis signaling molecule.]
Worst Severity Past Seven Days Breast Area Enlargement or Tenderness	NCIT_C132209	[A question about an individual's observation of the worst severity they have experienced related to breast area enlargement or tenderness over the past seven days.]
TBC-CEA-Contaminated W/ BVDV	NCIT_C29476	[A cancer vaccine consisting of a recombinant vector encoding the tumor-associated carcinoembryonic antigen (CEA) that is contaminated with bovine viral diarrhea virus (BVDV). The carcinoembryonic antigen (CEA) is a prevalent tumor marker expressed by a number of different cancers such as colorectal, breast, lung and ovarian carcinomas; vaccination with vaccinia virus genetically engineered to express CEA may generate antitumoral T-cell responses. BVDV is an RNA pestivirus that may contaminate vaccines due to its presence in fetal calf serum used as a growth supplement in the tissue culture of mammalian cells used in vaccine production. (NCI04)]