Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Geminin	NCIT_C29620	[Geminin (209 aa, ~24 kDa) is encoded by the human GMNN gene. This protein is involved in the modulation of DNA replication.]
Gallium Ga 68-NODAGA-ZIGF-1R:4:40	NCIT_C132030	[A radiolabeled recombinant insulin-like growth factor 1 receptor (IGF-1R; IGF1R)-specific affibody ligand composed of an IGF1R-targeting protein, the anti-IGF1R affibody ZIGF-1R:4:40 with an acetylated cysteine (Ac-Cys) at the N terminal of the affibody, that is site-specifically conjugated with the chelating agent NODAGA (1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid), and labeled with the radioisotope gallium Ga 68, with potential use for imaging IGF1R-expressing tumor cells upon positron emission tomography (PET). Upon administration of gallium Ga 68-NODAGA-ZIGF-1R:4:40, the ZIGF-1R:4:40 affibody molecule moiety targets and binds to IGF1R expressed on various tumor cell types. Upon PET, IGF1R-expressing tumor cells can be visualized. IGF1R, frequently overexpressed in cancers, plays important roles in cell proliferation, survival, adhesion, migration, and differentiation. The affibody protein scaffold is based on the Z-domain, which is derived from one of the immunoglobulin (Ig) G-binding domains of staphylococcal protein A.]
Cell Surface A33 Antigen	NCIT_C29621	[Cell surface A33 antigen (319 aa, ~36 kDa) is encoded by the human GPA33 gene. This protein may be involved in cell-cell interactions.]
GPA33 Gene	NCIT_C24441	[This gene plays a role in transcription and is a member of the immunoglobulin superfamily.]
NLRC5 Gene	NCIT_C132031	[This gene is involved in innate immunity and antiviral responses.]
NLRC5 wt Allele	NCIT_C132032	[Human NLRC5 wild-type allele is located in the vicinity of 16q13 and is approximately 94 kb in length. This allele, which encodes protein NLRC5, plays a role in signaling, immunity and antiviral processes.]
16q13	NCIT_C26014	[A chromosome band present on 16q]
Protein NLRC5	NCIT_C132033	[Protein NLRC5 (1866 aa, ~205 kDa) is encoded by the human NLRC5 gene. This protein is involved in signaling pathways and antiviral responses.]
CMTR2 Gene	NCIT_C132034	[This gene plays a role in the methylation of the 5' mRNA cap.]
CMTR2 wt Allele	NCIT_C132035	[Human CMTR2 wild-type allele is located in the vicinity of 16q22.2 and is approximately 8 kb in length. This allele, which encodes cap-specific mRNA (nucleoside-2-O-)-methyltransferase 2 protein, is involved in modification of mRNA.]
16q22.2	NCIT_C13643	[A chromosome band present on 16q]
Cap-Specific mRNA (Nucleoside-2-O-)-Methyltransferase 2	NCIT_C132036	[Cap-specific mRNA (nucleoside-2-O-)-methyltransferase 2 (770 aa, ~88 kDa) is encoded by the human CMTR2 gene. This protein plays a role in mRNA maturation.]
Fatty Acid-Binding Protein, Intestinal	NCIT_C29616	[Fatty acid-binding protein, intestinal (132 aa, ~15 kDa) is encoded by the human FABP2 gene. This protein plays a role in binding to saturated long-chain fatty acids with a high affinity and to unsaturated long-chain fatty acids with less affinity.]
Blasts 5-30 Percent of Bone Marrow Nucleated Cells	NCIT_C146689	[A semi-quantitative microscopic finding indicating that between 5 and 30 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells.]
Fatty Acid-Binding Protein, Adipocyte	NCIT_C29617	[Fatty acid-binding protein, adipocyte (132 aa, ~15 kDa) is encoded by the human FABP4 gene. This protein is involved in binding to both long chain fatty acids and retinoic acid.]
Therapeutic Androstanolone	NCIT_C29618	[A therapeutic anabolic steroid hormone identical to endogenous dihydrotestosterone. Androstanolone binds to and activates specific nuclear receptors. This agent may be used for testosterone replacement therapy in hypogonadal men, in HIV-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass. (NCI04)]
Dihydrotestosterone	NCIT_C29619	[The most potent androgen, required for sex development. Dihydrotestosterone is synthesized from testosterone in the prostate gland, testes, hair follicles and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates specific nuclear androgen receptors. After translocation into the nucleus, the activated hormone-receptor complex binds to the androgen response elements on the DNA and activates gene expressions that are required for sex development. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice.]
Androgen	NCIT_C2298
Perineal Pain, CTCAE 5.0	NCIT_C146681	[A disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus.]
Phantom Pain, CTCAE 5.0	NCIT_C146682	[A disorder characterized by a sensation of marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.]