Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
TBP-Associated Factor Gene	NCIT_C20539	[Control of transcription by RNA polymerase involves the basal transcription machinery, a collection of proteins which include TFIIB, TFIIE, TFIIF, TATA-box binding protein (TBP), TFIIA and TAF1. These, with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TBP-associated factors (TAFs) encoded by these TBP-Associated Factor Genes. Different TAFs may mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. (from OMIM 600772 and NCI)]
Interleukin-1	NCIT_C20506	[Interleukin-1 (endogenous pyrogen), produced primarily by monocytes, is an important pro-inflammatory cytokine that mediates the acute phase host response. The biologic activities of IL1 are properties of a protein derived from a larger precursor. Inflammation causes induction of COX2, leading to release of prostanoids, which sensitize peripheral nociceptor terminals and produce local pain hypersensitivity. Inflammation also generates sensitivity in neighboring tissue, muscle and joint pain, fever, lethargy, and anorexia. COX2 induction in regions of the CNS is mediated by IL1B. Interleukin-1-beta also stimulates bone resorption. IL1RN is a competitive inhibitor of IL1B. Mature IL1-beta levels are a sensitive and specific indicator of caspase-1 activation. (from OMIM 147720 and NCI)]
Interleukin-2	NCIT_C20507	[Interleukin-2 (153 aa, ~18 kDa) is encoded by the human IL2 gene. This protein is involved in T-cell proliferation, leukocyte stimulation and immune responses.]
Interleukin-4	NCIT_C20508	[Interleukin-4 (153 aa, ~17 kDa) is encoded by the human IL4 gene. This protein is involved in the regulation of the expression of class II MHC molecules, Fc receptors and cell surface-bound immunoglobulins.]
TAF2 Gene	NCIT_C20501	[This gene plays a role in transcriptional initiation.]
TAF3 Gene	NCIT_C20502	[This gene plays a role in transcriptional initiation and promoter recognition.]
TAF4 Gene	NCIT_C20503	[This gene plays a role in CREB mediated transcriptional initiation.]
EPDS - I Have Felt Sad or Miserable	NCIT_C132570	[Edinburgh Postnatal Depression Scale (EPDS) I have felt sad or miserable.]
EPDS Questionnaire Question	NCIT_C132528	[A question associated with the EPDS questionnaire.]
Cell Maintenance	NCIT_C20504	[Processes that promote, sustain, and preserve cell viability. (NCI)]
EPDS - So Unhappy I Have Been Crying	NCIT_C132571	[Edinburgh Postnatal Depression Scale (EPDS) I have been so unhappy that I have been crying.]
EPDS - Thought of Harming Myself	NCIT_C132572	[Edinburgh Postnatal Depression Scale (EPDS) The thought of harming myself has occurred to me.]
HAQ-DI Without VAS - Dress Yourself	NCIT_C132573	[Dressing & Grooming: Are you able to dress yourself, including tying shoelaces and doing buttons?]
HAQ-DI Without VAS - Shampoo Your Hair	NCIT_C132574	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Dressing & Grooming: Are you able to shampoo your hair?]
Tumor Necrosis Factor Family Protein	NCIT_C20500	[Family of cell surface proteins structurally related to tumor necrosis factor. They are involved in lymphocyte homeostasis by their ability to induce apoptosis.]
Cytokine	NCIT_C20464	[A class of soluble glycoproteins which act nonenzymatically through specific receptors to regulate immune responses. Cytokines are derived from both immune and non-immune cells and are intercellular mediators that differ from hormones in that they are produced by a number of tissue or cell types rather than by specialized glands.]
HAQ-DI Without VAS - Stand Up From a Straight Chair	NCIT_C132575	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Arising: Are you able to stand up from a straight chair?]
HAQ-DI Without VAS - Aid: Built Up or Special Utensils	NCIT_C132587	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Aids or devices that you usually use for any of these activities: Built up or special utensils.]
HAQ-DI Without VAS - Aid: Special or Built Up Chair	NCIT_C132588	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Aids or devices that you usually use for any of these activities: Special or built up chair.]
HAQ-DI Without VAS - Other Aid (Dress or Arising or Eat or Walk)	NCIT_C132589	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Aids or devices that you usually use for any of these activities: Other (for dressing and grooming, arising, eating and walking).]