Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Viral Protein	NCIT_C17254	[Proteins encoded by viral genes.]
GAG Gene	NCIT_C16614	[This gene is involved in retroviral core structure.]
ISWI Family Protein	NCIT_C20592	[The Drosophila gene Imitation SWI (Iswi) encodes a DNA helicase involved in chromatin modeling. It contains a SNF2 related domain, a MYB DNA binding domain, a DEAD/DEAH box helicase, and a helicase C-terminal domain. Iswi is a component of a 215 kD protein NURF, a nucleosome remodeling complex that facilitates the perturbation of chromatin structure in an ATP-dependent manner. Iswi mediates the hydrolysis of ATP during the remodeling of chromatin. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor ACF and of the chromatin accessibility complex CHRAC. This subunit may serve as the energy-transducing component of chromatin-remodeling machines. Iswi belongs to the SNF2/RAD54 helicase family, SNF2L subfamily. Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, Plasmodium falciparum, and Saccharomyces cerevisiae. (from FlyBase 0011604 and NCI)]
Drosophila Protein	NCIT_C20159	[Proteins found in Drosophila.]
Drosophila	NCIT_C14202	[A genus of small, American flies, Diptera. The best known species is D. Melanogaster, often called the fruit fly, but more correctly termed the vinegar fly. First investigated by T.H.Morgan and his group, it has been extensively used in genetic studies. More recently it has been used for studies of embryonic development.]
Nucleosome	NCIT_C13268	[A DNA packaging complex comprised of approximately 200 base pairs of DNA wound around a protein core, which is formed by an octomer of histones. The histone octomer includes two dimers of histones H2A and H2B that surround a tetramer consisting of two molecules of histone H3 and two molecules of histone H4.]
TFIIH	NCIT_C20593	[TFIIH is a multisubunit factor consisting of at least 5 polypeptides of 92, 62, 43, 40, and 35 kD. The nonphosphorylated form of RNA polymerase II is recruited by TFIIF to the DB complex (a DNA-protein complex composed of the TATA-binding protein subunit of TFIID in association with the TATA motif and TFIIB). This complex is then recognized by TFIIE, TFIIH, and TFIIJ to generate a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation. The general transcription factor TFIIH contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. (from OMIM 189972)]
RecQ Helicase Family Protein	NCIT_C20595	[RecQ family proteins are 3'-5' DNA helicases. All RecQ family proteins include a domain of approx. 450 amino acids that contains seven highly conserved motifs, including a 'Walker A-box' ATP-binding motif and a DExH box which is a characteristic of this family. These motifs are found in several DNA and RNA helicases.]
Capsaicinoid	NCIT_C68530
Bioactive Food Component	NCIT_C54060
Dihydrocapsaicin	NCIT_C68531
Arylesterase	NCIT_C20590	[Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. [EC 3.1.1.2 created 1961, modified 1989] (from IUBMB Enzyme Nomenclature).]
Coumestan	NCIT_C68532
SWI/SNF Family Complex	NCIT_C20591	[Involved in transcriptional activation of numerous genes, yeast SWI2/SNF2 contains a highly conserved domain among helicases required for transcriptional activity. Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes implicated in regulation of gene expression, cell cycle control, and oncogenesis. The SWI/SNF complex is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. The complex contains an ATP-dependent nucleosome disruption activity that can lead to enhanced binding of transcription factors. During mitosis, the human protein is phosphorylated, excluded from condensed chromosomes, and the protein level is strongly reduced. (from OMIM 600014 and NCI)]
Hydroxybenzoic Acid	NCIT_C68533
Hepatojugular	NCIT_C107530	[Of, or pertaining to, the liver and jugular vein.]
Pancreatic Stellate Cell	NCIT_C107531	[A star-shaped, myofibroblast-like cell in the pancreas associated with tissue maintenance. When pancreatic stellate cells are activated in response to an injury, they proliferate and synthesize large amounts of extracellular matrix. Pancreatic cancer cells can increase the activation of pancreatic stellate cells, which leads to fibrosis.]
Connective and Soft Tissue Cell	NCIT_C12555	[A non-epithelial cell of mesodermal origin that is found in mesenchymal tissue and functions to support, surround, or protect other structures or organs in the body.]
As Much As Possible	NCIT_C107521	[A response that indicates the largest amount imagined.]
Did You Take Any Medication Except the Study Drug for Vomiting in the Past 24 Hours	NCIT_C107522	[A question about whether an individual took any medication, except the study drug, for vomiting in the past 24 hours.]