Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Tannin | NCIT_C68538 | |
| GTF2A1L Gene | NCIT_C20597 | [This gene plays a role in germ cell-specific transcription.] |
| Hydrolyzable Tannin | NCIT_C68539 | |
| GTF2A2 Gene | NCIT_C20598 | [This gene is involved in transcriptional initiation.] |
| TBP Inhibitor Gene | NCIT_C20599 | [The assembly of transcription complexes at eukaryotic promoters involves a number of distinct steps, including chromatin remodeling and recruitment of a TATA-binding protein (TBP)-containing complexes, the RNA polymerase II holoenzyme. Each of these stages is controlled by positive and negative factors that regulate the interactions of TBP with promoter DNA. The magnitude by which an activated gene is expressed, might depend in part on competition between TBP inhibitors and the holoenzyme for access to the TBP/TATA complex. The first is autorepression, where TBP sequesters its DNA-binding surface through dimerization. Once TBP is bound to DNA, TAF(II)250 and Mot1 induce TBP to dissociate, while NC2 and the NOT complex convert the TBP/DNA complex into an inactive state. TFIIA antagonizes these TBP repressors only in conjunction with the recruitment of the RNA polymerase II holoenzyme by promoter-bound activators. (from PMID 10974559)] |
| Caffeic Acid | NCIT_C68540 | [An orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activities. Upon administration, caffeic acid acts as an antioxidant and prevents oxidative stress, thereby preventing DNA damage induced by free radicals. Caffeic acid targets and inhibits the histone demethylase (HDM) oncoprotein gene amplified in squamous cell carcinoma 1 (GASC1; JMJD2C; KDM4C) and inhibits cancer cell proliferation. GASC1, a member of the KDM4 subgroup of Jumonji (Jmj) domain-containing proteins, demethylates trimethylated lysine 9 and lysine 36 on histone H3 (H3K9 and H3K36), and plays a key role in tumor cell development.] |
| Proanthocyanidin | NCIT_C68541 | |
| Terpene | NCIT_C68542 | |
| Limonene | NCIT_C68543 | [An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes.] |
| How Much Nausea During This Period | NCIT_C107520 | [A question about how much nausea an individual experienced during the specified time period.] |
| Alkaline Phosphatase, Placental Type | NCIT_C107554 | [Alkaline phosphatase, placental type (535 aa, ~58 kDa) is encoded by the human ALPP gene. This protein plays a role in phosphate metabolism.] |
| Alkaline Phosphatase | NCIT_C16276 | [An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum.] |
| Folate Biosynthesis Pathway | NCIT_C38809 | |
| ALPP Gene | NCIT_C107487 | [This gene plays a role in phosphatase activity in the placenta.] |
| Bufalin | NCIT_C107555 | [An active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in cancer cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.] |
| Metanephrine | NCIT_C107556 | [A product of the O-methylation of epinephrine by catechol O-methyltransferase, which has no physiologic activity. Increased levels of free metanephrine in patient blood plasma samples may be a diagnostic indicator for pheochromocytoma.] |
| CYP3A Gene Locus | NCIT_C107557 | [Human CYP3A gene locus is located within 7q21.3-q22.1 and is approximately 218 kb in length. This locus includes four protein-encoding genes, CYP3A4, CYP3A5, CYP3A7 and CYP3A43, and two pseudogenes, CYP3A5P1 and CYP3A5P2. The protein-encoding genes are involved in drug metabolism and the biosynthesis of cholesterol, steroids and other lipids.] |
| B-Cell Receptor Complex | NCIT_C107558 | [A membrane bound protein complex comprised of an immunoglobulin molecule associated with a heterodimer, called CD79, containing one CD79A protein and one CD79B protein. The immunoglobulin determines the ligand specificity of the complex and the CD79 heterodimer promotes signal transduction. This receptor is involved in antigen processing and presentation.] |
| Casein Kinase 2 | NCIT_C107559 | [A serine/threonine kinase that is a tetrameric protein complex comprised of 2 catalytic alpha subunits and 2 regulatory beta subunits. This kinase complex is involved in the modulation of many cellular processes, including cell cycle progression and apoptosis regulation.] |
| Mucilage | NCIT_C68501 |