Terminology Service < Semantic Lookup Platform

All terms in RGD

Label	Id	Description
Cycs	rgd:2451	[ENCODES a protein that exhibits enzyme binding; electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity (ortholog); heme binding (ortholog); INVOLVED IN apoptotic process; glial cell apoptotic process; mitochondrial electron transport, cytochrome c to oxygen; PARTICIPATES IN intrinsic apoptotic pathway; cardiolipin metabolic pathway; ceramide signaling pathway; ASSOCIATED WITH brain ischemia (ortholog); Chloracne (ortholog); cholangiocarcinoma (ortholog); FOUND IN cytosol; mitochondrion; cytoplasm (ortholog); INTERACTS WITH (+)-taxifolin; (R)-adrenaline; (R)-lipoic acid]
LOC102547699	rgd:7668114
Cyct	rgd:2452	[ENCODES a protein that exhibits heme binding (ortholog); INVOLVED IN hydrogen peroxide metabolic process (ortholog); positive regulation of intrinsic apoptotic signaling pathway (ortholog); PARTICIPATES IN Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; apoptotic cell death pathway; FOUND IN respirasome (inferred); INTERACTS WITH 17beta-estradiol; ammonium chloride; bisphenol A]
Cyp11b1	rgd:2453	[ENCODES a protein that exhibits steroid 11-beta-monooxygenase activity; steroid binding; INVOLVED IN adenosine metabolic process; aldosterone biosynthetic process; cellular response to interferon-gamma; PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; ASSOCIATED WITH increased systemic arterial systolic blood pressure; ASSOCIATED WITH Fetal Growth Retardation; hypertension; Left Ventricular Hypertrophy; FOUND IN integral component of endoplasmic reticulum membrane; mitochondrion]
Cyp11b2	rgd:2454	[ENCODES a protein that exhibits corticosterone 18-monooxygenase activity; steroid 11-beta-monooxygenase activity; heme binding (ortholog); INVOLVED IN aldosterone biosynthetic process; C21-steroid hormone biosynthetic process; cellular response to mechanical stimulus; PARTICIPATES IN C21-steroid hormone biosynthetic pathway; 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH abnormal adrenal gland morphology; decreased heart left ventricle weight; increased circulating aldosterone level; ASSOCIATED WITH Albuminuria; Cardiomegaly; congestive heart failure; FOUND IN dendrite; mitochondrion (ortholog); INTERACTS WITH (S)-nicotine; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine]
Cyp17a1	rgd:2456	[ENCODES a protein that exhibits steroid 17-alpha-monooxygenase activity; 17-alpha-hydroxyprogesterone aldolase activity (ortholog); heme binding (ortholog); INVOLVED IN adrenal gland development; biphenyl metabolic process; cellular response to antibiotic; PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH sciatic neuropathy; 17,20-Lyase Deficiency, Isolated (ortholog); amenorrhea (ortholog); FOUND IN cell projection; endoplasmic reticulum; intracellular membrane-bounded organelle; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane]
Cyp19a1	rgd:2457	[ENCODES a protein that exhibits aromatase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding (ortholog); INVOLVED IN adrenal gland development; androgen metabolic process; bile acid metabolic process; PARTICIPATES IN aromatase inhibitor pathway; estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental ; Diabetic Nephropathies; endometriosis; FOUND IN axon terminus; cytoplasm; cytosol; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; (S)-naringenin]
Cyp1a1	rgd:2458	[ENCODES a protein that exhibits catalytic activity; demethylase activity; enzyme binding; INVOLVED IN 9-cis-retinoic acid biosynthetic process; aging; camera-type eye development; PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; tryptophan metabolic pathway; retinol metabolic pathway; ASSOCIATED WITH Acute Lung Injury; Diabetes Mellitus, Experimental ; end stage renal failure; FOUND IN cytoplasm; intracellular membrane-bounded organelle; mitochondrial inner membrane; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-epicatechin-3-O-gallate]
Cyp1a2	rgd:2459	[ENCODES a protein that exhibits monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; caffeine oxidase activity (ortholog); INVOLVED IN cellular response to copper ion; response to drug; response to estradiol; PARTICIPATES IN caffeine pharmacokinetics pathway; clomipramine pharmacokinetics pathway; clopidogrel pharmacodynamics pathway; ASSOCIATED WITH Jaundice; Liver Injury; mental depression; FOUND IN intracellular membrane-bounded organelle; INTERACTS WITH (+)-alpha-tocopherol; (+)-artemisinin; (+)-schisandrin B]
LOC108351920	rgd:11373714
LOC100909828	rgd:6501716
Cyp1b1	rgd:2460	[ENCODES a protein that exhibits monooxygenase activity; oxidoreductase activity; estrogen 16-alpha-hydroxylase activity (ortholog); INVOLVED IN adrenal gland development; benzene-containing compound metabolic process; cellular aromatic compound metabolic process; PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; steroid hormone biosynthetic pathway; tryptophan metabolic pathway; ASSOCIATED WITH breast adenocarcinoma; Cardiomegaly; esophagus squamous cell carcinoma; FOUND IN intracellular membrane-bounded organelle; nucleus; mitochondrion (ortholog); INTERACTS WITH 1,2,3,4,6,7,8-Heptachlorodibenzodioxin; 1,2,3,4,6,7,8-Heptachlorodibenzofuran; 1,2,3,4,7,8-Hexachlorodibenzofuran]
LOC100909831	rgd:6501719	[ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); INVOLVED IN detection of chemical stimulus involved in sensory perception of smell (inferred); FOUND IN integral component of membrane (inferred); plasma membrane (inferred)]
Cyp21a1	rgd:2461	[ENCODES a protein that exhibits steroid 21-monooxygenase activity; INVOLVED IN C21-steroid hormone biosynthetic process; cellular response to peptide hormone stimulus; mineralocorticoid biosynthetic process; PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; ASSOCIATED WITH congenital adrenal hyperplasia (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; beta-naphthoflavone]
Cyp24a1	rgd:2462	[ENCODES a protein that exhibits 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; vitamin D 24-hydroxylase activity; INVOLVED IN vitamin D catabolic process; vitamin D metabolic process; osteoblast differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); hypercalcemia (ortholog); Hypercalcemia, Infantile, 1 (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3-chloropropane-1,2-diol]
Cyp2a1	rgd:2463	[ENCODES a protein that exhibits oxidoreductase activity; steroid hydroxylase activity; INVOLVED IN coumarin metabolic process; PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; caffeine metabolic pathway; retinol metabolic pathway; FOUND IN intracellular membrane-bounded organelle; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 1,3,5-trinitro-1,3,5-triazinane]
Cyp2a2	rgd:2464	[ENCODES a protein that exhibits steroid hydroxylase activity; PARTICIPATES IN caffeine metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH (S)-nicotine; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether]
Cyp2a3	rgd:2465	[ENCODES a protein that exhibits aromatase activity (inferred); heme binding (inferred); iron ion binding (inferred); INVOLVED IN cellular response to cadmium ion (ortholog); heme metabolic process (ortholog); response to stilbenoid (ortholog); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Coumarin Resistance (ortholog); Coumarin Sensitivity (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); integral component of membrane (inferred); INTERACTS WITH (S)-nicotine; 1H-pyrazole; 2,3,7,8-tetrachlorodibenzodioxine]
Cyp2b1	rgd:2466	[ENCODES a protein that exhibits Hsp70 protein binding; Hsp90 protein binding; steroid hydroxylase activity; INVOLVED IN drug metabolic process; response to calcium ion; response to drug; PARTICIPATES IN arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; ASSOCIATED WITH Acute Lung Injury; Breast Neoplasms; Diabetes Mellitus, Experimental ; FOUND IN intracellular membrane-bounded organelle; mitochondrial inner membrane; INTERACTS WITH (+)-artemisinin; (-)-cotinine; (R)-camphor]
Cyp2b2	rgd:2467	[ENCODES a protein that exhibits oxidoreductase activity; steroid hydroxylase activity; INVOLVED IN aging; drug metabolic process; nicotine metabolic process; PARTICIPATES IN arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; ASSOCIATED WITH Inflammation; FOUND IN intracellular membrane-bounded organelle; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dichloroethene; 1,4-dioxane]