Terminology Service < Semantic Lookup Platform

All terms in RGD

Label	Id	Description
Casp1	rgd:2274	[ENCODES a protein that exhibits scaffold protein binding; CARD domain binding (ortholog); cysteine-type endopeptidase activity (ortholog); INVOLVED IN apoptotic process; lung development; memory; PARTICIPATES IN interleukin-1 signaling pathway; type II interferon signaling pathway; amyotrophic lateral sclerosis pathway; ASSOCIATED WITH acute kidney failure; Brain Injuries; Diabetes Mellitus, Experimental ; FOUND IN cytoplasm; neuron projection; nucleus; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol]
Casp3	rgd:2275	[ENCODES a protein that exhibits cysteine-type peptidase activity; death receptor binding; phospholipase A2 activator activity; INVOLVED IN apoptotic process; axonal fasciculation; cellular response to organic cyclic compound; PARTICIPATES IN intrinsic apoptotic pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH Acute Liver Failure; Acute Lung Injury; acute myocardial infarction; FOUND IN cytoplasm; cytosol; death-inducing signaling complex; INTERACTS WITH (+)-alpha-tocopherol; (+)-artemisinin; (+)-pilocarpine]
LOC103695184	rgd:9432993
LOC103694478	rgd:9393063
Casq2	rgd:2276	[ENCODES a protein that exhibits protein homodimerization activity; protein kinase C binding; calcium ion binding (ortholog); INVOLVED IN negative regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac muscle cell contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH congestive heart failure; Diabetic Cardiomyopathies; supravalvular aortic stenosis; FOUND IN sarcoplasmic reticulum; Z disc; cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; all-trans-retinoic acid]
Casr	rgd:2277	[ENCODES a protein that exhibits integrin binding; ion channel binding; protein kinase binding; INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; apoptotic process; bile acid secretion; PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH Albuminuria; atherosclerosis; cardiomyopathy; FOUND IN apical plasma membrane; axon; axon terminus; INTERACTS WITH 6-propyl-2-thiouracil; aluminium atom; aluminium(0)]
LOC100271845	rgd:2304343	[INTERACTS WITH sodium arsenite (ortholog); valproic acid (ortholog)]
Trnaq-cug4	rgd:11504996	[This record represents a tRNA model predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).]
Cast	rgd:2278	[ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase inhibitor activity; protease binding; INVOLVED IN aging; animal organ regeneration; brain development; PARTICIPATES IN the proteolytic pathway involving calcium-dependent proteases; ASSOCIATED WITH Brain Injuries; brain ischemia; Chemical and Drug Induced Liver Injury; FOUND IN cytoplasm; membrane; nucleus; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione]
LOC108350528	rgd:11504997
Cat	rgd:2279	[ENCODES a protein that exhibits catalase activity; aminoacylase activity (ortholog); antioxidant activity (ortholog); INVOLVED IN aging; cellular response to growth factor stimulus; hydrogen peroxide catabolic process; PARTICIPATES IN disulfiram pharmacodynamics pathway; tryptophan metabolic pathway; amyotrophic lateral sclerosis pathway; ASSOCIATED WITH bacterial pneumonia; brain ischemia; Bronchopulmonary Dysplasia; FOUND IN cytosol; endoplasmic reticulum; extracellular space; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (+)-schisandrin B]
LOC100365492	rgd:2318988
Aldh2	rgd:69219	[ENCODES a protein that exhibits aldehyde dehydrogenase (NAD+) activity; identical protein binding; NADH binding; INVOLVED IN acetaldehyde metabolic process; apoptotic mitochondrial changes; behavioral response to ethanol; PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH alcohol aversion; alcohol preference; ASSOCIATED WITH Alcoholic Fatty Liver; Chemical and Drug Induced Liver Injury; heart disease; FOUND IN mitochondrial matrix; mitochondrion; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene]
LOC102555066	rgd:7502898
LOC108349475	rgd:11479482
Cav1	rgd:2280	[ENCODES a protein that exhibits ion channel binding; kinase binding; nitric-oxide synthase binding; INVOLVED IN animal organ regeneration; cellular calcium ion homeostasis; cellular response to mechanical stimulus; PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; ASSOCIATED WITH Acute Lung Injury; Alcoholic Liver Diseases; atherosclerosis; FOUND IN basal plasma membrane; caveola; cell surface; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol]
Cav3	rgd:2281	[ENCODES a protein that exhibits enzyme binding; ion channel binding; molecular adaptor activity; INVOLVED IN cell differentiation; cellular response to organonitrogen compound; negative regulation of cell growth involved in cardiac muscle cell development; PARTICIPATES IN platelet-derived growth factor signaling pathway; endocytosis pathway; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis; myocardial infarction; Cardiomegaly (ortholog); FOUND IN caveola; cell surface; cytoplasm; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A]
LOC108349700	rgd:11479491
Runx2	rgd:2282	[ENCODES a protein that exhibits histone deacetylase binding; transcription factor binding; bHLH transcription factor binding (ortholog); INVOLVED IN cellular response to fibroblast growth factor stimulus; osteoblast differentiation; positive regulation of ossification; PARTICIPATES IN fibroblast growth factor signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Bone Fractures; Heterotopic Ossification; Hyperoxaluria; FOUND IN nucleus; cytoplasm (ortholog); nuclear chromatin (ortholog); INTERACTS WITH (20S)-ginsenoside Rg3; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol]
Runx1	rgd:2283	[ENCODES a protein that exhibits promoter-specific chromatin binding; sequence-specific double-stranded DNA binding; calcium ion binding (ortholog); INVOLVED IN ovulation; positive regulation of progesterone secretion; positive regulation of transcription, DNA-templated; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; acute myeloid leukemia pathway; chronic myeloid leukemia pathway; ASSOCIATED WITH Bone Fractures; endometriosis; middle cerebral artery infarction; FOUND IN nucleus; basement membrane (ortholog); intracellular membrane-bounded organelle (ortholog); INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol]