Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Solute carrier family 49 member 4 | Q8BFQ6 | [Function: Electrogenic metabolite transporter.] |
| RUN and SH3 domain-containing protein 1 | Q8BG26 | [Function: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.] |
| Fos-related antigen 1 | P48755 | |
| Gastric inhibitory polypeptide | P48756 | [Function: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.] |
| UDP-GalNAc_beta-1,3-N-acetylgalactosaminyltransferase 2 | Q8BG28 | [Function: Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity).] |
| Glutamine amidotransferase-like class 1 domain-containing protein 1 | Q8BFQ8 | |
| 26S proteasome non-ATPase regulatory subunit 11 | Q8BG32 | [Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.] |
| Follistatin-related protein 5 | Q8BFR2 | |
| UBX domain-containing protein 10 | Q8BG34 | [Function: VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia. UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97.] |
| N-acetylglucosamine-6-sulfatase | Q8BFR4 | |
| Elongation factor Tu, mitochondrial | Q8BFR5 | [Function: Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.] |
| Tubulin-specific chaperone A | O75347 | [Function: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.] |
| Cytochrome c oxidase subunit 7A2, mitochondrial | P48771 | [Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.] |
| V-type proton ATPase subunit G 1 | O75348 | [Function: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).] |
| Cytochrome c oxidase subunit 8B, mitochondrial | P48772 | [Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.] |
| Negative elongation factor A | Q8BG30 | [Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity).] |
| Zinc finger protein 253 | O75346 | [Function: May function as a transcription factor. Seem to have a transcriptional repression activity.] |
| Vexin | Q8BG31 | [Function: Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis (PubMed:29518376).] |
| Zinc finger CCCH-type antiviral protein 1-like | Q8BFR1 | |
| Guanylate cyclase soluble subunit beta-2 | O75343 |