Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Cytochrome P450 2B1	P00176	[Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.]
Testis-expressed protein 52	Q3TTI8
Akirin-2	Q53H80	[Function: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).]
Tripartite motif-containing protein 67	Q6ZTA4
RRP12-like protein	Q6P5B0
Endoribonuclease LACTB2	Q53H82	[Function: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.]
Eukaryotic translation initiation factor 3 subunit B	Q8JZQ9	[Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.]
Dehydrogenase/reductase SDR family member 7B	Q6IAN0	[Function: Putative oxidoreductase.]
Trimeric intracellular cation channel type B	Q9DAV9	[Function: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.]
Electroneutral sodium bicarbonate exchanger 1	Q8JZR6	[Function: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.]
Excitatory amino acid transporter 5	Q8JZR4	[Function: Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing (By similarity).]
BTB/POZ domain-containing protein 17	Q9DB72
NADH-cytochrome b5 reductase 1	Q9DB73	[Function: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.]
Long-chain-fatty-acid--CoA ligase 5	Q8JZR0	[Function: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL (By similarity). May have a role in the survival of glioma cells (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity).]
FUN14 domain-containing protein 1	Q9DB70	[Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.]
ER membrane protein complex subunit 9	Q9DB76
N-acetyltransferase family 8 member 2	P85118	[Function: Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4.]
YrdC domain-containing protein, mitochondrial	Q3U5F4	[Function: May regulate the activity of some transporters.]
Cytochrome b-c1 complex subunit 2, mitochondrial	Q9DB77	[Function: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex (By similarity).]
Cell death-inducing p53-target protein 1	Q9DB75	[Function: Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner (By similarity).]