Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Cytochrome b	P00159	[Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.]
Adenylate cyclase type 2	P26769	[Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:22906005, PubMed:24363043, PubMed:10427002, PubMed:1719547, PubMed:7761832, PubMed:21596131, PubMed:11087399, PubMed:15591060, PubMed:19243146, PubMed:16766715). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production (PubMed:24363043). Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (PubMed:22906005).]
Ribosomal RNA-processing protein 8	Q9DB85	[Function: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity).]
Cytochrome b	P00156	[Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.]
U4/U6 small nuclear ribonucleoprotein Prp4	Q9DAW6	[Function: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).]
Mesoderm-specific transcript homolog protein	Q6P5P5
E3 ubiquitin-protein ligase ZNRF4	Q9DAH2	[Function: E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (By similarity). Could have a role in spermatogenesis (Probable).]
SCP2 sterol-binding domain-containing protein 1	Q9DAH1
GREB1-like protein	B9EJV3	[Function: Plays a major role in early metanephros and genital development.]
Tetratricopeptide repeat protein 9C	Q6P5P3
Protein FAM135B	Q9DAI6
Zinc finger and BTB domain-containing protein 43	Q9DAI4	[Function: May be involved in transcriptional regulation.]
Peroxisomal membrane protein 2	Q07066	[Function: Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.]
MORN repeat-containing protein 5	Q9DAI9
Cytoskeleton-associated protein 4	Q07065	[Function: Mediates the anchoring of the endoplasmic reticulum to microtubules.]
Ankyrin repeat domain-containing protein 13D	Q6ZTN6	[Function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.]
Intraflagellar transport protein 22 homolog	Q9DAI2	[Function: Small GTPase-like component of the intraflagellar transport (IFT) complex B.]
Glutamyl aminopeptidase	Q07075	[Function: Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.]
Glucokinase regulatory protein	Q07071	[Function: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23957911). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23957911).]
WD repeat domain-containing protein 83	Q9DAJ4	[Function: Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing.]