Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Putative uncharacterized protein LOC400499	Q6ZTK2
Humanin-like 8	P0CJ75	[Function: Plays a role as a neuroprotective and antiapoptotic factor.]
Humanin-like 9	P0CJ76	[Function: Plays a role as a neuroprotective and antiapoptotic factor.]
UPF0524 protein C3orf70	A6NLC5
Dynein assembly factor 5, axonemal	B9EJR8	[Function: Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.]
60S ribosomal protein L18	Q07020	[Function: Component of the large ribosomal subunit.]
Humanin-like 6	P0CJ73	[Function: Plays a role as a neuroprotective and antiapoptotic factor.]
Humanin-like 7	P0CJ74	[Function: Plays a role as a neuroprotective and antiapoptotic factor.]
T cell receptor beta variable 11-1	A0A0K0K1C0	[Function: V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).]
UMP-CMP kinase 2, mitochondrial	Q3U5Q7	[Function: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity).]
Vimentin-type intermediate filament-associated coiled-coil protein	Q6QZQ4
Humanin-like 4	P0CJ71	[Function: Plays a role as a neuroprotective and antiapoptotic factor.]
Humanin-like 5	P0CJ72	[Function: Plays a role as a neuroprotective and antiapoptotic factor.]
Mesenteric estrogen-dependent adipogenesis protein	Q14BA6	[Function: Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.]
Humanin-like 3	P0CJ70	[Function: Plays a role as a neuroprotective and antiapoptotic factor.]
Fibronectin type 3 and ankyrin repeat domains 1 protein	Q9DAM9	[Function: Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.]
EARP and GARP complex-interacting protein 1	Q53HC9	[Function: Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.]
Transmembrane protein 263	Q9DAM7
Zinc finger protein 888	P0CJ79	[Function: May be involved in transcriptional regulation.]
Complement component 1 Q subcomponent-binding protein, mitochondrial	Q07021	[Function: (Microbial infection) Involved in replication of Rubella virus.]