Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Kelch-like protein 36	Q8R124	[Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.]
von Willebrand factor A domain-containing protein 2	Q70UZ7
Aspartate beta-hydroxylase domain-containing protein 2	Q6ICH7	[Function: May function as 2-oxoglutarate-dependent dioxygenase.]
Saccharopine dehydrogenase-like oxidoreductase	Q8R127
p21-activated protein kinase-interacting protein 1	Q9DCE5	[Function: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.]
Postacrosomal sheath WW domain-binding protein	Q6ICG8	[Function: May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.]
G2/mitotic-specific cyclin-B3	Q810T2	[Function: Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity).]
Histone acetyltransferase KAT7	Q810T5	[Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1. Specifically represses AR-mediated transcription.]
Ras-related protein Rap-1b-like protein	A6NIZ1
Coiled-coil domain-containing protein 136	Q3TVA9	[Function: May play a role in acrosome formation in spermatogenesis and in fertilization.]
Cytochrome c oxidase subunit 3	P00414	[Function: Subunits I, II and III form the functional core of the enzyme complex.]
Cytochrome c oxidase subunit 3	P00416	[Function: Subunits I, II and III form the functional core of the enzyme complex.]
B box and SPRY domain-containing protein	Q5W0U4	[Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity.]
LHFPL tetraspan subfamily member 2 protein	Q6ZUX7	[Function: Plays a role in female and male fertility. Involved in distal reproductive tract development.]
Uncharacterized protein KIAA0930	Q6ICG6
Transmembrane protein 119	Q8R138	[Function: Plays an important role in bone formation and normal bone mineralization (PubMed:26207632, PubMed:22416756, PubMed:20025746). Promotes the differentiation of myoblasts into osteoblasts (PubMed:22416756, PubMed:20025746, PubMed:22579779). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway (PubMed:21239498, PubMed:22579779). Upregulates the expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451). Essential for normal spermatogenesis and late testicular differentiation (PubMed:26207632).]
Equilibrative nucleoside transporter 4	Q8R139	[Function: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorptprev reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (By similarity).]
Translocon-associated protein subunit gamma	Q9DCF9	[Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.]
Coiled-coil domain-containing protein 50	Q810U0	[Function: Involved in EGFR signaling.]
Coiled-coil domain-containing protein 50	Q810U5	[Function: Involved in EGFR signaling.]