Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Matrilysin	Q10738	[Function: May play a role in tissue reorganization.]
Matrix metalloproteinase-14	Q10739	[Function: Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.]
Acyl-coenzyme A oxidase-like protein	Q9DBS4
Kinesin light chain 4	Q9DBS5	[Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).]
Pre-mRNA-processing factor 17	Q9DC48	[Function: Required for pre-mRNA splicing as component of the activated spliceosome.]
Centrosomal protein POC5	Q9DBS8	[Function: Essential for the assembly of the distal half of centrioles, required for centriole elongation.]
Oxysterol-binding protein-related protein 3	Q9DBS9	[Function: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.]
Calcineurin B homologous protein 2	Q810D1	[Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus (By similarity).]
Protein yippee-like 3	P61236	[Function: Involved in proliferation and apoptosis in myeloid precursor cells.]
Endogenous retrovirus group K member 10 Gag polyprotein	P87889	[Function: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.]
Glutamate-rich WD repeat-containing protein 1	Q810D6	[Function: Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.]
Branched-chain-amino-acid aminotransferase, cytosolic	P24288	[Function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.]
Purkinje cell protein 4-like protein 1	A6NKN8
Tumor protein p63-regulated gene 1-like protein	Q9DBS2	[Function: Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release.]
Telomere length regulation protein TEL2 homolog	Q9DC40	[Function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).]
Protein yippee-like 3	P61237	[Function: Involved in proliferation and apoptosis in myeloid precursor cells.]
Transmembrane protein 43	Q9DBS1	[Function: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane.]
DNA-directed RNA polymerase III subunit RPC7-like	Q8R0C0	[Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.]
DDB1- and CUL4-associated factor 17	Q3TUL7	[Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.]
Testis anion transporter 1	Q8R0C3	[Function: Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation (By similarity).]