Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Aldo-keto reductase family 1 member D1	P51857	[Function: Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one).]
ATP-binding cassette sub-family G member 8	Q9DBM0	[Function: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:25378657). Plays an important role in preventing the accumulation of dietary plant sterols in the body (PubMed:12444248, PubMed:14657202). Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG5 has ATPase activity (PubMed:16352607, PubMed:16867993).]
G patch domain-containing protein 1	Q9DBM1
Nuclear receptor 2C2-associated protein	Q3TV70	[Function: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.]
Hepatoma-derived growth factor	P51858	[Function: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719).]
Hepatoma-derived growth factor	P51859	[Function: Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity).]
Peroxisomal bifunctional enzyme	Q9DBM2
Putative 60S ribosomal protein L37a-like protein	A6NKH3
Fatty acid-binding protein, brain	P51880	[Function: B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.]
Pecanex-like protein 2	A6NKB5	[Function: May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H).]
ADP-ribosylation factor-like protein 4C	P61208	[Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process (By similarity).]
ADP/ATP translocase 2	P51881	[Function: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).]
T-cell surface glycoprotein CD5	P51882	[Function: May act as a receptor in regulating T-cell proliferation.]
Transmembrane 4 L6 family member 4	P48230	[Function: Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.]
Sprouty-related, EVH1 domain-containing protein 3	Q6P6N5	[Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.]
Probable ATP-dependent RNA helicase DDX59	Q9DBN9
Prolargin	P51888	[Function: May anchor basement membranes to the underlying connective tissue.]
Lumican	P51884
Lumican	P51885
Histone H1t	Q07133	[Function: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration.]