Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Phosphoinositide 3-kinase adapter protein 1 | Q6ZUJ8 | [Function: Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.] |
| Solute carrier family 46 member 3 | Q9DC26 | |
| Protein-associating with the carboxyl-terminal domain of ezrin | Q9DBQ7 | [Function: May play a role in regulating cell adhesion/migration complexes in migrating cells.] |
| Rabankyrin-5 | Q810B6 | [Function: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport (By similarity). Involved in macropinocytosis; the function is dependent on Rab5-GTP.] |
| ADP-ribosylation factor-like protein 4A | P61213 | [Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).] |
| ADP-ribosylation factor-like protein 4A | P61214 | [Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).] |
| ADP-ribosylation factor-like protein 1 | P61211 | [Function: GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity).] |
| Brain-specific homeobox protein homolog | Q810B3 | [Function: DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance.] |
| ADP-ribosylation factor-like protein 1 | P61212 | [Function: GTP-binding protein. Can activate phospholipase D with very low efficiency (By similarity). Important for normal function of the Golgi apparatus.] |
| SLIT and NTRK-like protein 3 | Q810B9 | [Function: Suppresses neurite outgrowth.] |
| DNA-directed RNA polymerases I, II, and III subunit RPABC2 | P61218 | [Function: DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).] |
| SLIT and NTRK-like protein 4 | Q810B8 | [Function: It is involved in synaptogenesis and promotes synapse differentiation (By similarity). Suppresses neurite outgrowth (PubMed:14550773).] |
| Carbonic anhydrase-related protein 10 | P61215 | [Function: Does not have a catalytic activity.] |
| SLIT and NTRK-like protein 5 | Q810B7 | [Function: Suppresses neurite outgrowth.] |
| Transcription initiation factor TFIID subunit 13 | P61216 | [Function: Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells (By similarity).] |
| Eukaryotic translation initiation factor 4E type 3 | Q9DBB5 | [Function: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.] |
| N-alpha-acetyltransferase 16, NatA auxiliary subunit | Q9DBB4 | [Function: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.] |
| Carboxypeptidase N subunit 2 | Q9DBB9 | [Function: The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit (By similarity).] |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | Q6DTY7 | [Function: Synthesis and degradation of fructose 2,6-bisphosphate.] |
| Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | Q9DBB8 |