Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Dihydrofolate reductase	P00374	[Function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.]
Nucleoside diphosphate-linked moiety X motif 13	Q8JZU0
Dihydrofolate reductase	P00375	[Function: Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (PubMed:25980602). Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (PubMed:25980602). Binds its own mRNA.]
Uncharacterized protein C8orf87	E5RJ46
Leucine-rich repeat-containing protein 3C	A6NJW4
Solute carrier family 2, facilitated glucose transporter member 2	P12336	[Function: Facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:3048704). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:3048704). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity). Also able to mediate the transport of dehydroascorbate (By similarity).]
T-cell surface glycoprotein CD8 beta-2 chain	A6NJW9	[Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity).]
Ras association domain-containing protein 10	A6NK89	[Function: Plays an important role in regulating embryonic neurogenesis.]
Transmembrane protein 18	Q3TUD9	[Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity).]
3-hydroxybutyrate dehydrogenase type 2	Q8JZV9	[Function: Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis (PubMed:20550936, PubMed:24863067). Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (PubMed:24863067). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).]
N-acetylglucosamine-6-phosphate deacetylase	Q8JZV7	[Function: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.]
Glutathione S-transferase theta-4	A0A1W2PR19	[Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.]
Cytochrome c oxidase subunit 7B, mitochondrial	P24311	[Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates.]
RNA-binding protein 41	Q8JZV4	[Function: May bind RNA.]
Cytochrome c oxidase subunit 7A1, mitochondrial	P24310	[Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.]
Protein FAM174C	Q9DAZ5
L-lactate dehydrogenase C chain	P00342	[Function: Possible role in sperm motility.]
Abscission/NoCut checkpoint regulator	Q9DAZ9	[Function: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity).]
Single-strand selective monofunctional uracil DNA glycosylase	Q53HV7	[Function: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.]
Protein FAM166C	A6NJV1