Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Putative beta-defensin 109B | Q30KR1 | [Function: Has antibacterial activity.] |
| Heterogeneous nuclear ribonucleoprotein C-like 2 | B2RXH8 | [Function: May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.] |
| Sperm acrosome membrane-associated protein 3 | Q8IXA5 | [Function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.] |
| BTB/POZ domain-containing protein 18 | B2RXH4 | [Function: Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.] |
| Histone H2A.J | A9UMV8 | [Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.] |
| Xin actin-binding repeat-containing protein 1 | Q702N8 | [Function: Protects actin filaments from depolymerization.] |
| Lysine-specific demethylase 4E | B2RXH2 | [Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.] |
| Jerky protein | Q60976 | [Function: May bind DNA.] |
| Nuclear receptor corepressor 1 | Q60974 | [Function: Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (PubMed:24794873). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (PubMed:19037247).] |
| Histone-binding protein RBBP7 | Q60973 | [Function: Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).] |
| Histone-binding protein RBBP4 | Q60972 | [Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).] |
| Fibromodulin | P50608 | [Function: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.] |
| Fibromodulin | P50609 | [Function: Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity).] |
| Zinc finger protein 680 | Q8NEM1 | [Function: May be involved in transcriptional regulation.] |
| Microcephalin | Q8NEM0 | [Function: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.] |
| SHC SH2 domain-binding protein 1 | Q8NEM2 | [Function: May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.] |
| Tubby protein homolog | P50607 | [Function: Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.] |
| Transcription factor SPT20 homolog | Q8NEM7 | [Function: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.] |
| Beta-defensin 112 | Q30KQ8 | [Function: Has antibacterial activity.] |
| Beta-defensin 113 | Q30KQ7 | [Function: Has antibacterial activity.] |