Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Ubiquitin-conjugating enzyme E2 J2	Q6P073	[Function: In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells. The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage.]
cAMP-dependent protein kinase inhibitor alpha	P63249	[Function: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.]
cAMP-dependent protein kinase inhibitor alpha	P63248	[Function: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.]
Serine protease 40	A6H6T1	[Function: May play an important role in the sperm/egg interaction; released during the acrosome reaction.]
NEDD4-binding protein 2-like 1	Q5TBK1
Receptor-type tyrosine-protein phosphatase mu	P28828	[Function: Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.]
Receptor-type tyrosine-protein phosphatase mu	P28827	[Function: Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.]
GATOR complex protein NPRL2	Q9WUE4	[Function: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.]
Cytochrome b561 domain-containing protein 2	Q9WUE3	[Function: Two-heme-containing cytochrome that catalyzes ascorbate-dependent trans-membrane ferric-chelate reduction.]
Meprin A subunit beta	P28826	[Function: Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.]
Meprin A subunit alpha	P28825
Sorcin	Q6P069	[Function: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.]
ADP-ribosylation factor-like protein 5C	Q6P068	[Function: Binds and exchanges GTP and GDP.]
Neuroendocrine convertase 1	P63239	[Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.]
TBC1 domain family member 2B	Q3U0J8	[Function: May act as a GTPase-activating protein.]
Tumor necrosis factor ligand superfamily member 13B	Q9WU72	[Function: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.]
Chitinase-3-like protein 1	Q9WTV1	[Function: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity).]
Syntaxin-binding protein 5	Q9WU70	[Function: Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity). Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding.]
Prolactin regulatory element-binding protein	Q9WTV0	[Function: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.]
Secernin-1	Q12765	[Function: Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).]