Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM44 | O43615 | [Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.] |
| Parvalbumin alpha | P02625 | [Function: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.] |
| Putative UPF0607 protein ENSP00000383144 | A8MX80 | |
| Programmed cell death protein 4 | Q53EL6 | [Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).] |
| Seizure protein 6 homolog | Q53EL9 | [Function: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity).] |
| Retrotransposon Gag-like protein 4 | Q6ZR62 | [Function: Involved in cognitive function in the brain, possibly via the noradrenergic system.] |
| Enoyl-CoA hydratase, mitochondrial | P14604 | [Function: Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.] |
| Substance-P receptor | P14600 | [Function: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.] |
| Neuronal migration protein doublecortin | O43602 | [Function: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.] |
| Heat shock protein beta-1 | P14602 | [Function: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity).] |
| Protein THEMIS2 | Q5TEJ8 | [Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.] |
| Galanin receptor type 2 | O43603 | [Function: Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).] |
| Protein sprouty homolog 1 | O43609 | [Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.] |
| Protein S100-G | P02634 | |
| Putative uncharacterized protein FLJ44672 | Q6ZQT7 | |
| Oncomodulin | P02631 | [Function: Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.] |
| cAMP-regulated phosphoprotein 19 | Q712U5 | [Function: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA.] |
| Golgin subfamily A member 6-like protein 4 | A6NEF3 | |
| Putative WAS protein family homolog 4 | A8MWX3 | [Function: May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.] |
| Zinc finger protein 493 | Q6ZR52 | [Function: May be involved in transcriptional regulation.] |