Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Serine/threonine-protein kinase LMTK2	Q8IWU2	[Function: Phosphorylates PPP1C, phosphorylase b and CFTR.]
Nephrocystin-1	O15259	[Function: Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity).]
Ig kappa chain V-V region J606	P01652
Ig kappa chain V-V region UPC 61	P01650
Cation channel sperm-associated protein 1	Q8NEC5	[Function: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.]
Ig kappa chain V-III region PC 6684	P01670
Glutathione S-transferase C-terminal domain-containing protein	Q8NEC7
Sodium/potassium-transporting ATPase subunit alpha-3	P13637	[Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.]
YjeF N-terminal domain-containing protein 3	A6XGL0	[Function: May play a role in spermiogenesis and oogenesis.]
Peroxisomal acyl-coenzyme A oxidase 3	O15254	[Function: Oxidizes the CoA-esters of 2-methyl-branched fatty acids.]
Elongation factor 2	P13639	[Function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.]
Sodium/potassium-transporting ATPase subunit beta-2	P13638	[Function: Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.]
Ceruloplasmin	P13635	[Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. May also play a role in fetal lung development or pulmonary antioxidant defense. involved in iron transport across the cell membrane (By similarity). Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1.]
Carbonic anhydrase 1	P13634	[Function: Reversible hydration of carbon dioxide.]
Retinoic acid receptor gamma	P13631	[Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).]
Kelch-like protein 10	Q6JEL2	[Function: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.]
Gap junction delta-2 protein	O54851	[Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.]
Ig kappa chain V-III region PC 7210	P01668
Ig kappa chain V-III region PC 7769	P01669
E3 ubiquitin-protein ligase UBR2	Q8IWV8	[Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (By similarity).]