Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Putative golgin subfamily A member 8D	Q0D2H9
DNA excision repair protein ERCC-6	F8VPZ5	[Function: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (By similarity). It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions (By similarity). Plays an important role in regulating the choice of the DNA double-strand breaks (DSBs) repair pathway and G2/M checkpoint activation; DNA-dependent ATPase activity is essential for this function (By similarity). Regulates the DNA repair pathway choice by inhibiting non-homologous end joining (NHEJ), thereby promoting the homologous recombination (HR)-mediated repair of DSBs during the S/G2 phases of the cell cycle (By similarity). Mediates the activation of the ATM- and CHEK2-dependent DNA damage responses thus preventing the premature exit from the G2/M checkpoint (By similarity). Acts as a chromatin remodeler at DSBs; DNA-dependent ATPase-dependent activity is essential for this function (By similarity). Remodels chromatin by evicting histones from chromatin flanking DSBs, limiting RIF1 accumulation at DSBs thereby promoting BRCA1-mediated HR (By similarity). Required for stable recruitment of ELOA and CUL5 to DNA damage sites (By similarity). Involved in UV-induced translocation of ERCC8 to the nuclear matrix (By similarity). Essential for neuronal differentiation and neuritogenesis; regulates transcription and chromatin remodeling activities required during neurogenesis (By similarity).]
Protein misato homolog 1	Q2YDW2	[Function: Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.]
N-lysine methyltransferase KMT5A	Q2YDW7	[Function: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration (By similarity).]
Transmembrane protein 191C	A6NGB0
Human immunodeficiency virus type I enhancer-binding protein 2 homolog	Q00900	[Function: Binds to DNA at the acute-phase response element of the angiotensinogen gene and related nuclear factor kappa-B binding sites through a zinc-finger motif.]
E3 ubiquitin-protein ligase RNF149	Q3U2C5	[Function: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.]
Nuclear pore complex-interacting protein family member B9	F8W1W9
Intermediate filament family orphan 1	Q0D2I5
Latent-transforming growth factor beta-binding protein 1	Q00918	[Function: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:7593177). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity).]
H-2 class II histocompatibility antigen, E-U alpha chain	P14439
Zinc finger and SCAN domain-containing protein 5C	A6NGD5	[Function: May be involved in transcriptional regulation.]
Zinc finger protein 155	Q12901	[Function: May be involved in transcriptional regulation.]
H-2 class II histocompatibility antigen, A-R alpha chain	P14436
H-2 class II histocompatibility antigen, A-F alpha chain	P14435
H-2 class II histocompatibility antigen, A-U alpha chain	P14438
H-2 class II histocompatibility antigen, A-S alpha chain	P14437
Interleukin enhancer-binding factor 2	Q12905	[Function: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.]
H-2 class I histocompatibility antigen, TLA(B) alpha chain	P14432	[Function: Involved in the presentation of foreign antigens to the immune system.]
Angiomotin-like protein 2	G3V735	[Function: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity).]