Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
H-2 class I histocompatibility antigen, Q7 alpha chain	P14429	[Function: Involved in the presentation of foreign antigens to the immune system.]
Short-wave-sensitive opsin 1	P51491	[Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors (PubMed:21219924, PubMed:25416279). Involved in ensuring correct abundance and localization of retinal membrane proteins (PubMed:25416279). May increase spectral sensitivity in dim light (PubMed:11055434).]
H-2 class I histocompatibility antigen, K-Q alpha chain	P14428	[Function: Involved in the presentation of foreign antigens to the immune system.]
TLC domain-containing protein 2	A6NGC4	[Function: Regulates the composition and fluidity of the plasma membrane (PubMed:30509349). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (PubMed:30509349). Does not appear to have any effect on LCPUFA synthesis (PubMed:30509349).]
OTU domain-containing protein 5	Q2YDU3	[Function: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity).]
EF-hand calcium-binding domain-containing protein 9	A8MZ26	[Function: pH-dependent Ca(2+) sensor required to activate the CatSper channel, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.]
H-2 class I histocompatibility antigen, D-P alpha chain	P14427	[Function: Involved in the presentation of foreign antigens to the immune system.]
Putative uncharacterized protein FLJ38767	A8MZ25
H-2 class I histocompatibility antigen, D-K alpha chain	P14426	[Function: Involved in the presentation of foreign antigens to the immune system.]
Phospholipase A2, membrane associated	P14423	[Function: Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:3356705). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Independent of its catalytic activity, activates integrins by binding to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and inducing integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity).]
Nuclear prelamin A recognition factor	Q2YDU6
Protein SMG5	Q6ZPY2	[Function: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity).]
Protein spinster homolog 1	Q2YDU8	[Function: Sphingolipid transporter. May be involved in necrotic or autophagic cell death (By similarity).]
H-2 class I histocompatibility antigen, Q8 alpha chain	P14430	[Function: Involved in the presentation of foreign antigens to the immune system.]
Type II inositol 3,4-bisphosphate 4-phosphatase	Q6P1Y8	[Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity).]
GRB2-associated-binding protein 2	Q9UQC2	[Function: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.]
Collagen alpha-1(II) chain	P02458	[Function: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.]
Calcium-activated chloride channel regulator 2	Q9UQC9	[Function: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.]
Valine--tRNA ligase, mitochondrial	Q3U2A8
Collagen alpha-1(I) chain	P02454	[Function: Type I collagen is a member of group I collagen (fibrillar forming collagen).]