Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Tissue-resident T-cell transcription regulator protein ZNF683	I7HJS4	[Function: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:22885984, PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T-cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:22885984, PubMed:27102484). Plays also a role in the differentiation of both thymic and peripheral NKT cells (PubMed:22885984). Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation (PubMed:22885984). Positively regulates granzyme B production in NKT cells after innate stimulation (PubMed:22885984). Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions (PubMed:27102484).]
Sulfotransferase family cytosolic 1B member 1	O43704	[Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.]
Feline leukemia virus subgroup C receptor-related protein 2	Q9UPI3	[Function: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.]
Zinc finger protein 710	Q3U288	[Function: May be involved in transcriptional regulation.]
Maleylacetoacetate isomerase	O43708	[Function: Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.]
Probable 18S rRNA (guanine-N(7))-methyltransferase	O43709	[Function: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).]
Alpha-actinin-4	O43707	[Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).]
LETM1 domain-containing protein 1	Q6P1Q0	[Function: Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.]
Cardiac-enriched FHL2-interacting protein	Q711Q0	[Function: Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway.]
Calcium-transporting ATPase type 2C member 2	A7L9Z8	[Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.]
Exocyst complex component 5	Q3TPX4	[Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.]
tRNA N(3)-methylcytidine methyltransferase METTL2B	Q6P1Q9	[Function: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).]
Protein EFR3 homolog B	Q6ZQ18	[Function: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.]
Probable ergosterol biosynthetic protein 28	Q9UKR5
Zinc finger protein 236	Q9UL36	[Function: May be involved in transcriptional regulation.]
Ubiquitin-conjugating enzyme E2 Q2	Q8K2Z8	[Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.]
Trafficking protein particle complex subunit 2-like protein	Q9UL33	[Function: Plays a role in vesicular transport from endoplasmic reticulum to Golgi.]
Kallikrein-13	Q9UKR3
Condensin complex subunit 1	Q8K2Z4	[Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.]
Tetraspanin-16	Q9UKR8