Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Zinc finger protein 215	Q9UL58	[Function: May be involved in transcriptional regulation.]
F-box only protein 4	Q9UKT5	[Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.]
Parathymosin	P04550	[Function: Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.]
Putative F-box/LRR-repeat protein 21	Q9UKT6	[Function: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).]
Zinc finger protein 214	Q9UL59	[Function: May be involved in transcriptional regulation.]
Zinc finger protein Aiolos	Q9UKT9	[Function: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.]
COP9 signalosome complex subunit 9	Q8WXC6	[Function: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.]
Proline-rich protein 30	Q9D9B7
Leucine-rich melanocyte differentiation-associated protein	Q9D9B4	[Function: Required for melanocyte differentiation.]
Pyrin domain-containing protein 1	Q8WXC3	[Function: Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.]
Thiopurine S-methyltransferase	O55060	[Function: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.]
Alpha-protein kinase 1	Q9CXB8	[Function: Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (By similarity). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (By similarity). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (By similarity).]
Taste receptor type 2 member 13	Q9JKT7	[Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.]
Glycerophosphodiester phosphodiesterase 1	Q9JL56	[Function: Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25596343). Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).]
Secreted and transmembrane protein 1b	Q9JL59	[Function: May be involved in thymocyte signaling.]
Taste receptor type 2 member 107	Q9JKT9	[Function: Putative taste receptor which may play a role in the perception of bitterness.]
Sorting nexin-32	Q86XE0	[Function: May be involved in several stages of intracellular trafficking.]
tRNA (cytosine(38)-C(5))-methyltransferase	O55055	[Function: Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).]
Taste receptor type 2 member 114	Q9JKT8	[Function: Putative taste receptor which may play a role in the perception of bitterness.]
Solute carrier family 10 member 6	Q9CXB2	[Function: Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.]