Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Protein FAM104B	Q5XKR9
ADP-sugar pyrophosphatase	Q9JKX6	[Function: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (By similarity). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10722730). Can also hydrolyze other nucleotide sugars with low activity (PubMed:10722730). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate (By similarity). Nuclear ATP synthesis takes place when dephosphorylated at Thr-44 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Does not play a role in U8 snoRNA decapping activity (PubMed:21070968). Binds U8 snoRNA (PubMed:21070968).]
Cathepsin M	Q9JL96
Condensin-2 complex subunit G2	Q86XI2	[Function: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.]
Zinc fingers and homeoboxes protein 1	Q9UKY1	[Function: Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.]
Chromodomain-helicase-DNA-binding protein 1-like	Q9CXF7	[Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (By similarity).]
C-type lectin domain family 1 member B	Q9JL99	[Function: C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2.]
TBC1 domain family member 15	Q9CXF4	[Function: Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.]
Uroplakin-3a	Q9JKX8	[Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).]
Transferrin receptor protein 2	Q9JKX3	[Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.]
Protein O-mannosyl-transferase 2	Q9UKY4	[Function: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129).]
Pre-mRNA-splicing factor CWC25 homolog	Q9NXE8	[Function: Involved in pre-mRNA splicing as component of the spliceosome.]
Proteoglycan 3	Q9JL95	[Function: Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP.]
Protein AATF	Q9JKX4	[Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity).]
Putative inactive carboxylesterase 4	Q9UKY3	[Function: Has no esterase activity.]
Sphingomyelin phosphodiesterase 4	Q9NXE4	[Function: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924).]
Uncharacterized protein ZSWIM9	Q86XI8
Protein CDV3 homolog	Q9UKY7
Ankyrin repeat and SOCS box protein 11	Q8WXH4	[Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.]
Cytochrome c oxidase subunit 7A-related protein, mitochondrial	Q61387	[Function: Involved in the regulation of oxidative phosphorylation and energy metabolism (PubMed:23857330, PubMed:23812712). Necessary for the assembly of mitochondrial respiratory supercomplex (PubMed:23857330, PubMed:23812712).]