Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| EF-hand domain-containing protein D2 | Q9D8Y0 | [Function: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.] |
| Transmembrane protein 126A | Q9D8Y1 | |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 | Q9JKL4 | [Function: Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).] |
| Probable tRNA(His) guanylyltransferase | Q9NWX6 | [Function: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.] |
| Ankyrin repeat and SOCS box protein 6 | Q9NWX5 | [Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.] |
| Syntabulin | Q9NX95 | [Function: Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.] |
| Homeobox protein ARX | Q96QS3 | [Function: Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate.] |
| Methyl-CpG-binding domain protein 3-like 1 | Q8WWY6 | [Function: Transcriptional repressor.] |
| WW domain binding protein 1-like | Q9NX94 | |
| Prokineticin receptor 1 | Q9JKL1 | [Function: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy (By similarity).] |
| Olfactory receptor 2A7 | Q96R45 | [Function: Odorant receptor.] |
| Lipase member H | Q8WWY8 | [Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).] |
| WAP four-disulfide core domain protein 12 | Q8WWY7 | [Function: Antibacterial protein. Putative acid-stable proteinase inhibitor.] |
| Serine/threonine-protein kinase H2 | Q96QS6 | |
| Tetraspanin-32 | Q96QS1 | |
| U4/U6 small nuclear ribonucleoprotein Prp31 | Q8WWY3 | [Function: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11867543, PubMed:28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed:11867543).] |
| Polypyrimidine tract-binding protein 1 | Q00438 | [Function: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (By similarity).] |
| Phosphatidylinositol glycan anchor biosynthesis class U protein | Q8K358 | [Function: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (By similarity).] |
| RNA polymerase II-associated factor 1 homolog | Q8K2T8 | [Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity).] |
| Olfactory receptor 2A14 | Q96R47 | [Function: Odorant receptor.] |