Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Zinc finger and SCAN domain-containing protein 1	Q8NBB4	[Function: May be involved in transcriptional regulation.]
Mitochondrial antiviral-signaling protein	Q66HG9	[Function: Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.]
Probable ATP-dependent RNA helicase DDX59	Q66HG7
Protein Red	Q66HG8	[Function: Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1.]
Glial cell line-derived neurotrophic factor	P39905	[Function: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.]
Macrophage metalloelastase	P39900	[Function: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.]
Cyclin-D-binding Myb-like transcription factor 1	Q66HG1	[Function: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'.]
Solute carrier family 26 member 9	Q7LBE3	[Function: DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.]
E3 ubiquitin-protein ligase RNF13	Q66HG0	[Function: E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA.]
Killer cell lectin-like receptor 7	Q60654	[Function: Receptor on natural killer (NK) cells for class I MHC.]
Transmembrane 9 superfamily member 2	Q66HG5	[Function: In the intracellular compartments, may function as a channel or small molecule transporter.]
Carbonic anhydrase 5B, mitochondrial	Q66HG6	[Function: Reversible hydration of carbon dioxide.]
Killer cell lectin-like receptor 6	Q60653	[Function: Receptor on natural killer (NK) cells for class I MHC.]
Serine/threonine-protein kinase MRCK alpha	Q3UU96	[Function: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LRP35A, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A and LIMK2. May play a role in TFRC-mediated iron uptake (By similarity). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (By similarity).]
Killer cell lectin-like receptor 5	Q60652	[Function: Receptor on natural killer (NK) cells for class I MHC.]
Beta-Ala-His dipeptidase	Q66HG3
Otoancorin	Q7RTW8	[Function: May act as an adhesion molecule.]
Aldose 1-epimerase	Q66HG4	[Function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).]
Killer cell lectin-like receptor 4	Q60651	[Function: Receptor on natural killer (NK) cells for class I MHC.]
Thrombospondin type-1 domain-containing protein 4	Q3UTY6	[Function: Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.]