Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Transmembrane 9 superfamily member 1	Q66HF2	[Function: Plays an essential role in autophagy.]
Monocarboxylate transporter 14	Q7RTX9	[Function: Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.]
Caseinolytic peptidase B protein homolog	Q60649	[Function: May function as a regulatory ATPase and be related to secretion/protein trafficking process.]
Ganglioside GM2 activator	Q60648	[Function: Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity.]
WD repeat-containing protein 37	Q8CBE3
Ceramide synthase 3	Q8IU89	[Function: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952). It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal. differentiation (PubMed:23754960).]
Calcium/calmodulin-dependent protein kinase type 1D	Q8IU85	[Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.]
Serine protease 48	Q7RTY5
Cyclin-dependent kinase-like 1	Q66HE7
Ovochymase-1	Q7RTY7
NUAK family SNF1-like kinase 2	Q66HE5	[Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).]
Monocarboxylate transporter 9	Q7RTY1	[Function: Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.]
Monocarboxylate transporter 13	Q7RTY0	[Function: Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.]
Calcium-binding and coiled-coil domain-containing protein 2	A2A6M5	[Function: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity).]
Putative serine protease 45	Q7RTY3
PR domain zinc finger protein 1	Q60636	[Function: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484).]
Flotillin-2	Q60634	[Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.]
Serine protease 41	Q7RTY9
COUP transcription factor 1	Q60632	[Function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity).]
Transmembrane protease serine 7	Q7RTY8	[Function: Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.]