Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Vacuolar protein sorting-associated protein 8 homolog | Q0P5W1 | [Function: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes (By similarity).] |
| Tax1-binding protein 1 homolog | Q66HA4 | [Function: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity).] |
| Mitogen-activated protein kinase kinase kinase 11 | Q66HA1 | [Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity).] |
| Cyclic AMP-responsive element-binding protein 3-like protein 1 | Q66HA2 | [Function: Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (By similarity).] |
| Uncharacterized protein KIAA1522 | A2A7S8 | |
| Heat shock protein 105 kDa | Q66HA8 | [Function: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.] |
| Coiled-coil and C2 domain-containing protein 1A | Q66HA5 | [Function: Transcription factor that binds specifically to the DRE (dual repressor element) and represses 5-HT1A gene transcription though this element. Mediates HDAC-independent repression of HTR1A promoter. CAMK2G inhibits CC2D1a-induced repression of the HTR1A. May play a role in the altered regulation of 5-HT1A receptors associated with anxiety and major depression. Performs essential function in controlling functional maturation of synapses (By similarity).] |
| ADP-ribosylation factor-like protein 8B | Q66HA6 | [Function: Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation (By similarity).] |
| Ankyrin repeat domain-containing protein 12 | Q6UB98 | [Function: May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.] |
| Ovostatin homolog | Q3UU35 | [Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.] |
| Ankyrin repeat domain-containing protein 11 | Q6UB99 | [Function: Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity).] |
| Protein inscuteable homolog | Q3HNM7 | [Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis (PubMed:16301171, PubMed:21816348). May regulate cell proliferation and differentiation in the developing nervous system (PubMed:16301171). May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (PubMed:16094321).] |
| Ankyrin repeat and LEM domain-containing protein 1 | Q8NAG6 | [Function: Endonuclease that probably plays a role in the DNA damage response and DNA repair.] |
| Uncharacterized protein SPEM2 | Q0P670 | |
| Alpha-actinin-3 | Q08043 | [Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.] |
| Protocadherin-11 Y-linked | Q9BZA8 | [Function: Potential calcium-dependent cell-adhesion protein.] |
| Coiled-coil domain-containing protein 142 | Q8CAI1 | |
| Zinc finger B-box domain-containing protein 1 | Q0P5X5 | |
| Hepatocyte growth factor | Q08048 | [Function: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.] |
| Putative transcript Y 10 protein | Q9BZA0 |