Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Protein FAM163A	Q8CAA5
Coiled-coil domain-containing protein 171	E9Q1U1
Putative uncharacterized protein encoded by LINC02694	Q8NAA6
Cytochrome P450 4F8	P98187	[Function: A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds, with preference for omega-1 and omega-2 positions (PubMed:10791960, PubMed:16112640, PubMed:15789615). Hydroxylates (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) predominantly at omega-2 position to form (18R)-hydroxyeicosatetraenoic acid (18R-HETE) (PubMed:10791960). Exhibits omega-1 hydroxylase activity toward prostaglandin (PG) H1, PGH2 and PGI2 (PubMed:10791960, PubMed:15789615). Catalyzes the epoxidation of double bonds of PUFAs, including docosahexaenoic and docosapentaenoic acids (PubMed:16112640). Shows little activity against PGD2, PGE1, PGE2, PGF2alpha, and leukotriene B4.]
Cytosolic arginine sensor for mTORC1 subunit 2	Q8CAB8	[Function: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.]
FAD-dependent oxidoreductase domain-containing protein 2	Q3USW5	[Function: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity).]
NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2	E9PQ53	[Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).]
Ribonuclease T2-B	C0HKG6	[Function: Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Probably is involved in lysosomal degradation of ribosomal RNA.]
Putative transcript Y 12 protein	Q9BZ98
Phosphatidate cytidylyltransferase 1	P98191	[Function: Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity).]
Dihydroxyacetone phosphate acyltransferase	P98192
Dentin matrix acidic phosphoprotein 1	P98193	[Function: May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).]
Calcium-transporting ATPase type 2C member 1	P98194	[Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.]
Leucine-rich repeat-containing protein 75A	Q8NAA5
Probable phospholipid-transporting ATPase IIB	P98195
Autophagy-related protein 16-2	Q8NAA4	[Function: May play a role in autophagy.]
L-lactate dehydrogenase A-like 6B	Q9BYZ2
Regenerating islet-derived protein 4	Q9BYZ8	[Function: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.]
Rho-related BTB domain-containing protein 2	Q9BYZ6
Paired amphipathic helix protein Sin3a	Q60520	[Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Required for cortical neuron differentiation and callosal axon elongation (PubMed:27399968).]