Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Podocalyxin-like protein 2 | Q8CAE9 | [Function: Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins (By similarity).] |
| Calcium-activated potassium channel subunit beta-1 | Q8CAE3 | [Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.] |
| Protein FAM205A-4 | C0HKD3 | |
| Microfibrillar-associated protein 1B | C0HKD9 | [Function: Involved in pre-mRNA splicing as a component of the spliceosome.] |
| Microfibrillar-associated protein 1A | C0HKD8 | [Function: Involved in pre-mRNA splicing as a component of the spliceosome.] |
| Small RNA 2'-O-methyltransferase | Q8CAE2 | [Function: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.] |
| Ubiquitin carboxyl-terminal hydrolase 8 | P40818 | [Function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062).] |
| Protein FAM205A-2 | C0HKD1 | |
| Protein FAM205A-3 | C0HKD2 | |
| Putative peripheral benzodiazepine receptor-related protein | B1AH88 | |
| Putative uncharacterized protein encoded by LINC01555 | Q8NAE3 | |
| NHS-like protein 1 | Q8CAF4 | |
| Regulator of telomere elongation helicase 1 | Q0VGM9 | [Function: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.] |
| Interferon regulatory factor 2-binding protein 2 | E9Q1P8 | [Function: Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation (By similarity).] |
| Sperm motility kinase 3A | C0HKC8 | [Function: May play a role in sperm motility, especially in the regulation of flagellar function.] |
| Sperm motility kinase 3B | C0HKC9 | [Function: May play a role in sperm motility, especially in the regulation of flagellar function.] |
| Putative homeobox protein Meis3-like 2 | A8K0S8 | |
| Endothelin-3 | P13207 | [Function: Endothelins are endothelium-derived vasoconstrictor peptides.] |
| Spermatid-associated protein | Q8NA61 | |
| Cyclic nucleotide-binding domain-containing protein 1 | Q8NA66 |