Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Hydroxymethylglutaryl-CoA synthase, mitochondrial	P54868	[Function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.]
6-phosphogluconate dehydrogenase, decarboxylating	P52209	[Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.]
Hydroxymethylglutaryl-CoA synthase, mitochondrial	P54869	[Function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.]
Transmembrane protein 70, mitochondrial	Q9BUB7	[Function: Involved in biogenesis of mitochondrial ATP synthase.]
Endothelin-converting enzyme 1	P42893	[Function: Converts big endothelin-1 to endothelin-1.]
Endothelin-converting enzyme 1	P42892	[Function: Converts big endothelin-1 to endothelin-1.]
tRNA-specific adenosine deaminase 1	Q9BUB4	[Function: Specifically deaminates adenosine-37 to inosine in tRNA-Ala.]
MAP kinase-interacting serine/threonine-protein kinase 1	Q9BUB5	[Function: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.]
Secretoglobin family 1D member 2	O95969	[Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.]
Thrombopoietin receptor	P40238	[Function: Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.]
EGF-containing fibulin-like extracellular matrix protein 2	O95967
Secretoglobin family 1D member 1	O95968	[Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.]
CD82 antigen	P40237	[Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.]
Methylenetetrahydrofolate reductase	P42898	[Function: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.]
L-dopachrome tautomerase	P29812	[Function: Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:1537333). Involved in regulating eumelanin and phaeomelanin levels.]
Anterior gradient protein 2 homolog	O95994	[Function: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113).]
Dynein regulatory complex subunit 4	O95995	[Function: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity).]
Cholesterol 25-hydroxylase	O95992	[Function: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.]
Interleukin-18-binding protein	O95998	[Function: Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.]
B-cell lymphoma/leukemia 10	O95999	[Function: Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).]