Terminology Service for NFDI4Health
All terms in UNIPROT
| Label | Id | Description |
|---|---|---|
| Uncharacterized protein C3orf20 | Q8ND61 | |
| Mitogen-activated protein kinase kinase kinase kinase 3 | Q8IVH8 | [Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.] |
| High affinity immunoglobulin epsilon receptor subunit beta | P13386 | [Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.] |
| Coiled-coil domain-containing protein 191 | Q8NCU4 | |
| Phosphatidylcholine translocator ABCB4 | Q08201 | [Function: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.] |
| C2 calcium-dependent domain-containing protein 4A | Q8NCU7 | [Function: May be involved in inflammatory process. May regulate cell architecture and adhesion.] |
| Methylmalonic aciduria type A protein, mitochondrial | Q8IVH4 | [Function: GTPase, binds and hydrolyzes GTP (PubMed:28497574, PubMed:20876572). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) and reactivation of the enzyme during catalysis (PubMed:28497574, PubMed:20876572).] |
| T-cell activation inhibitor, mitochondrial | P0DKR2 | [Function: May regulate T-cell apoptosis.] |
| Inhibitory synaptic factor 1 | Q8CD60 | [Function: Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.] |
| Transcription factor TFIIIB component B'' homolog | Q571C7 | [Function: General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site (By similarity).] |
| Putative uncharacterized protein encoded by LINC00587 | B1AMM8 | |
| Galectin-related protein | Q3ZCW2 | [Function: Does not bind lactose, and may not bind carbohydrates.] |
| Ankyrin repeat domain-containing protein 31 | A0A140LI88 | [Function: Required for DNA double-strand breaks (DSBs) formation during meiotic recombination (PubMed:31003867, PubMed:31000436). Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation (PubMed:31003867, PubMed:31000436). Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes (PubMed:31000436).] |
| Vacuolar protein sorting-associated protein 51 homolog | Q3UVL4 | [Function: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.] |
| Serine-rich and transmembrane domain-containing protein 1 | Q8CD78 | |
| F-box/WD repeat-containing protein 8 | P0DL28 | [Function: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain.] |
| T-cell surface glycoprotein CD5 | P13379 | [Function: May act as a receptor in regulating T-cell proliferation.] |
| Adenosine deaminase domain-containing protein 2 | Q8NCV1 | |
| GTPase IMAP family member 8 | Q8ND71 | [Function: Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.] |
| Nostrin | Q8IVI9 | [Function: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.] |