Terminology Service < Semantic Lookup Platform

All terms in UNIPROT

Label	Id	Description
Leukemia inhibitory factor receptor	P42702	[Function: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.]
C-C motif chemokine 27	Q9Y4X3	[Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.]
Interleukin-12 receptor subunit beta-1	P42701	[Function: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.]
Muellerian-inhibiting factor	P27106	[Function: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.]
Erythrocyte band 7 integral membrane protein	P27105	[Function: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.]
Lutropin-choriogonadotropic hormone receptor	P30730	[Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.]
Ankyrin repeat and SOCS box protein 1	Q9Y576	[Function: May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.]
Deubiquitinase DESI2	Q9BSY9	[Function: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520).]
Probable G-protein coupled receptor 83	P30731	[Function: Orphan receptor. Could be a neuropeptide Y receptor.]
E3 ubiquitin-protein ligase TRIM17	Q9Y577	[Function: May function as a ubiquitin E3 ligase.]
Protein FAM187B	Q0VAY3
Cellular retinoic acid-binding protein 1	P29762	[Function: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.]
Receptor-interacting serine/threonine-protein kinase 3	Q9Y572	[Function: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.]
Actin-binding protein IPP	Q9Y573	[Function: May play a role in organizing the actin cytoskeleton.]
Ankyrin repeat and SOCS box protein 4	Q9Y574	[Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).]
Ankyrin repeat and SOCS box protein 3	Q9Y575	[Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.]
Mast cell protease 2	P15119
Cadherin-2	P15116	[Function: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell (PubMed:2762814, PubMed:11433297, PubMed:17988630, PubMed:9655503, PubMed:25253890). Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.]
Leukemia inhibitory factor	P17777	[Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.]
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5	Q9BSY4